Student difficulties during structure-function problem solving
Student difficulties during structure-function problem solving
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DOI：
10.1002/bmb.21166
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发表时间：
2018-09-01
影响因子：
1.4
通讯作者：
Lemons, Paula P.
中科院分区：
文献类型：
--
作者：
Halmo, Stephanie M.;Sensibaugh, Cheryl A.;Lemons, Paula P.
蛋白质结构-功能是生物化学中的一个关键概念。我们使用特定领域问题解决的视角来研究学生对明确定义的蛋白质结构功能问题的解决方案。我们对 13 名本科生进行了有声思考访谈，并进行了定性内容分析，以检查正确和错误解决方案之间的通用领域知识和特定领域知识的差异。我们的工作表明，学生在解决问题时使用了通用领域和特定领域的知识。我们还发现了学生在氨基酸主链、氨基酸分类和非共价相互作用的因果机制方面的困难。利用所发现的困难，我们提出了教学材料设计的建议，旨在提高生物化学课堂上蛋白质结构-功能问题的解决。 （c）2018年国际生物化学与分子生物学联合会，46（5）：453-463，2018年。
Protein structure-function is a key concept in biochemistry. We used the perspective of domain-specific problem-solving to investigate students' solutions to a well-defined protein structure-function problem. We conducted think-aloud interviews with 13 undergraduate students and performed qualitative content analysis to examine the differences in the domain-general and domain-specific knowledge among correct and incorrect solutions. Our work revealed that students used domain-general and domain-specific knowledge in their problem solving. We also identified difficulties for students with the amino acid backbone, amino acid categorization, and causal mechanisms of noncovalent interactions. Using the identified difficulties, we make recommendations for the design of instructional materials targeted to improve protein structure-function problem solving in the biochemistry classroom. (c) 2018 International Union of Biochemistry and Molecular Biology, 46(5):453-463, 2018.