Weight change, weight change intention, and the incidence of mobility limitation in well-functioning community-dwelling older adults
Weight change, weight change intention, and the incidence of mobility limitation in well-functioning community-dwelling older adults
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DOI：
10.1093/gerona/60.8.1007
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发表时间：
2005-08-01
影响因子：
5.1
通讯作者：
Newman, AB
中科院分区：
文献类型：
--
作者：
Lee, JS;Kritchevsky, SB;Newman, AB
背景。肥胖会增加晚年功能衰退的风险，但体重变化对老年人的功能影响目前尚不清楚。本研究的目的是确定体重、体重改变和体重改变意图是否与老年人活动受限的风险相关。这项研究包括2932名70至79岁的身体机能良好的黑人和白人男性和女性，他们参加了健康、衰老和身体组成（健康ABC）研究，随访了30个月。在基线，报告的体重变化5磅或以上的前一年和体重改变的意图进行评估。活动受限被定义为在30个月内连续两次半年一次的评估中报告行走四分之一英里或爬10级台阶的困难或无法行走。大约30%的参与者出现了行动能力限制。较高的身体质量指数（BMI）与活动受限的风险增加有关。前一年意外减肥与极度肥胖者（定义为BMI >= 35）和正常BMI（定义为BMI < 25）的活动受限风险增加相关（风险比[HR] = 3.79； 95%可信区间[CI]， 1.84-7.79）。在BMI为25至29.9的人群中，有意减肥（HR, 1.59; 95% CI, 1.12-2.25）和有意体重波动（HR, 1.59; 95% CI, 1.10-2.28）增加了活动受限的风险。与体重稳定相比，无意的体重增加或波动不会带来额外的活动受限风险，无论体重水平如何。在这组功能良好的老年人中，过去体重变化的功能后果取决于体重变化的类型、意向性和当前测量的体重。
Background. Obesity increases the risk for functional decline in later years, but the functional consequences of weight change in older adults are currently Unclear. The aim Of this Study was to determine whether weight, weight change, and weight change intention are associated with risk for mobility limitation in elderly persons.Methods. This study included 2932 well-functioning black and white men and women aged 70 to 79 years, participating in the Health, Aging and Body Composition (Health ABC) Study, who were followed for 30 months. At baseline, reported weight change of 5 or more pounds during the previous year and weight change intention were assessed. Mobility limitation was defined as reported difficulty or inability to walk one-quarter mile or to climb 10 steps during two consecutive semiannual assessments during a period of 30 months.Results. Approximately 30% of participants developed mobility limitation. Higher body mass index (BMI) was associated with increased risk for mobility limitation. Unintentional weight loss in the previous year was associated with increased risk for mobility limitation in the extremely obese, which wits defined as BMI >= 35 (hazard ratios [HR], = 3.79; 95% confidence interval [CI], 1.84-7.79), and the normal BMI, which was defined as BMI < 25 (HR, 2.55; 95% CI, 1.80-3.60). In persons with BMI 25 to 29.9, intentional weight loss (HR, 1.59; 95% CI, 1.12-2.25) and weight fluctuation with any intention (HR, 1.59; 95% CI, 1.10-2.28) increased the risk for mobility limitation. Unintentional weight gain Or fluctuation did not confer additional risk for mobility limitation compared with weight stability, regardless of the level of body weight.Conclusion. In this cohort of well-functioning elderly persons, functional consequences of past weight change depended on the type of weight change, intentionality, and current measured body weight.