Effect of helminth-induced immunity on infections with microbial pathogens.
Effect of helminth-induced immunity on infections with microbial pathogens.
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DOI：
10.1038/ni.2736
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发表时间：
2013-11
影响因子：
30.5
通讯作者：
Gause WC
中科院分区：
文献类型：
--
作者：
Salgame P;Yap GS;Gause WC
蠕虫感染在世界范围内普遍存在，可引发与宿主对微生物病原体的保护反应不同的有效免疫反应，并可能拮抗宿主的保护反应。在这篇综述中，我们聚焦于传染病的三种主要杀手——艾滋病、结核病和疟疾，并批判性地评估寄生虫是否对这些疾病的宿主控制产生不利影响。我们还讨论了关于M2巨噬细胞和蠕虫调节的树突状细胞如何潜在地影响并发感染的保护性免疫反应的新兴概念。最后，我们提出的证据支持更多的努力，以确定蠕虫如何以及在多大程度上干扰成功控制特定的并发共感染。
Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease—AIDS, tuberculosis and malaria—and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections.