Determination of Cervical Lymph Nodes Metastasis and Extra Nodal Extension Status by Quantitative Assessment of Border Irregularity and Apparent Diffusion Coefficient in Patients With Tongue Squamous Cell Carcinoma
Determination of Cervical Lymph Nodes Metastasis and Extra Nodal Extension Status by Quantitative Assessment of Border Irregularity and Apparent Diffusion Coefficient in Patients With Tongue Squamous Cell Carcinoma
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DOI：
10.1097/rct.0000000000001170
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发表时间：
2021-05
影响因子：
1.3
通讯作者：
Gongxin Yang;M. Rao;Jiliang Ren;Xing Yang;Jingbo Wang;Yingwei Wu;X. Tao
中科院分区：
文献类型：
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作者：
Gongxin Yang;M. Rao;Jiliang Ren;Xing Yang;Jingbo Wang;Yingwei Wu;X. Tao
目的探讨定量边界不规则性评价和表观扩散系数(ADC)对舌鳞状细胞癌(SCCT)的诊断价值。方法对63例SCCT患者的192个颈部淋巴结进行MRI检查，包括头颈部常规序列、动态增强磁共振成像、弥散加权成像、ADC值、表面规则性(SR)和视觉评价变量，并于术后进行病理评估。结果坏死、淋巴门、边界不清、SR高、长短轴比、ADC值与颈淋巴转移(M-cLns)、结外转移(ENE)及单纯ENE结缘增厚有关。Logistic回归分析显示，表观弥散系数、SR、边界不清、可见坏死与M-CLN密切相关，而SR、边界不清、可见坏死与ENE状态相关。结论定量SR和ADC数据显著提高了SCCT患者M-cLns和ENE的诊断水平。
Objective The objective of this study was to determine the diagnostic value of quantitative border irregularity assessment and apparent diffusion coefficient (ADC) in patients with squamous cell carcinoma of the tongue (SCCT). Methods Cervical lymph nodes (n = 192) from 63 patients with SCCT were examined preoperatively by magnetic resonance imaging, including routine head and neck sequences, dynamic contrast-enhanced magnetic resonance imaging, diffusion-weighted imaging, ADC, surface regularity (SR), and visually assessed variables, and evaluated pathologically after surgery. Results Necrosis, lymphatic hilum, unclear margin, higher SR, long to short axis ratio, and ADC were associated with metastasis in cervical lymph nodes (M-cLNs) and extranodal extension (ENE), and thickened nodal rim with ENE alone. Apparent diffusion coefficient, SR, unclear margin, and visible necrosis were strongly associated with M-cLN, whereas SR, unclear margin, and visible necrosis were associated with ENE status on logistic regression analysis. Conclusions Quantitative SR and ADC data greatly improved diagnosis of M-cLNs and ENE, relative to visible variables alone in patients with SCCT.