Breast cancer predisposition and brain hemispheric laterality specification likely share a common genetic cause.
Breast cancer predisposition and brain hemispheric laterality specification likely share a common genetic cause.
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DOI：
10.3233/bd-2010-0318
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Klar, Amar J S
中科院分区：
文献类型：
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作者：
Klar, Amar J S
大多数女性乳腺癌病例仍然无法用简单的孟德尔遗传学来解释。通常假设这种非家族性的所谓散发病例是由于受影响的个体暴露于致癌环境和/或随机细胞生物学错误造成的。显然，不良环境暴露会导致疾病，但这一定是大多数散发病例的原因吗？奇怪的是，据报道，与一般公众相比，选择右手使用的女性乳腺癌患者表现出更高的大脑半球偏侧性发生率。值得注意的是，这种较高水平的半球反转也存在于健康的左撇子或双手灵巧的人身上。基于这些不同特征之间的关联，本文提出了散发性乳腺癌病例病因学的新假设；乳腺癌易感性和大脑偏侧性发育可能有共同的遗传原因。
The majority of breast cancer cases seen in women remain unexplained by simple Mendelian genetics. It is generally hypothesized that such non-familial, so-called sporadic cases, result from exposure of the affected individuals to a cancer-causing environment and/or from stochastic cell biological errors. Clearly, adverse environment exposure can cause disease, but is that necessarily the cause of most sporadic cases? Curiously, female breast cancer patients who were selected to prefer right-hand-use reportedly exhibited a higher incidence of reversed-brain hemispheric laterality when compared to that of the public at large. Notably, such a higher level of hemispheric reversal is also found in healthy, left-handed or ambidextrous persons. Based on the association between these disparate traits, a new hypothesis for the etiology of sporadic breast cancer cases is advanced here; breast cancer predisposition and brain laterality development likely share a common genetic cause.