Methyleugenol Potentiates Central Amygdala GABAergic Inhibition and Reduces Anxiety
Methyleugenol Potentiates Central Amygdala GABAergic Inhibition and Reduces Anxiety
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甲基丁香酚增强中央杏仁核 GABA 能抑制并减少焦虑
DOI：
10.1124/jpet.118.250779
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发表时间：
2019-01-01
影响因子：
3.5
通讯作者：
Li, Fei
中科院分区：
文献类型：
--
作者：
Liu, Yan-Mei;Fan, Hui-Ran;Li, Fei
中央杏仁核（CeA）在情绪行为的表达中起着关键作用，包括病理性焦虑症。本研究表明，GABA能抑制CeA显着增加甲基丁香酚（ME），从几种植物的精油分离的天然成分。电生理记录表明，ME使CeA脑片的紧张性和抑制性突触后GABA能电流均增加，尤其是紧张性电流，而对兴奋性突触后GABA能电流无明显影响。在恐惧诱导的焦虑动物模型中，腹腔注射或CeA特异性输注ME均减少小鼠的焦虑样行为，可能是通过促进A型GABA受体（GABAARs）的激活。这些结果表明，GABAAR在CeA可以是一个潜在的治疗靶点，用于治疗焦虑症和ME是能够加强GABA能抑制CeA神经元的神经元兴奋性的抑制。
The central amygdala (CeA) plays a critical role in the expression of emotional behaviors, including pathologic anxiety disorders. The present study demonstrated that GABAergic inhibition in CeA was significantly increased by methyleugenol (ME), a natural constituent isolated from the essential oils of several plants. The electrophysiologic recordings showed that ME increased both tonic and miniature inhibitory postsynaptic GABAergic currents in CeA slices, especially the tonic currents, while the miniature excitatory postsynaptic currents were not affected. In the fear-induced anxiety animal model, both intraperitoneal injection or CeA-specific infusion of ME reduced the anxiety-like behaviors in mice, likely by facilitating the activation of A-type GABA receptors (GABAARs). These results reveal that GABAAR in the CeA can be a potential therapeutic target for the treatment of anxiety and that ME is capable of enhancing the GABAergic inhibition in CeA neurons for the inhibition of neuronal excitability.