Intracellular injections of BAPTA block induction of enhancement in Hermissenda type B-photoreceptors.

Intracellular injections of BAPTA block induction of enhancement in Hermissenda type B-photoreceptors.
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细胞内注射 BAPTA 可阻断 Hermissenda B 型光感受器增强的诱导。

DOI:
10.1016/0304-3940(92)90771-x
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发表时间:
1992
影响因子:
2.5
通讯作者:
Crow,T
Crow,T
中科院分区:
医学4区
文献类型:
--
作者:
Falk-Vairant,J;Crow,T

文献摘要

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Light paired with serotonin (5-HT) in vivo produces both short- and long-term enhancement of generator potentials in identified B-photoreceptors inHermissenda. The role of intracellular Ca2+in the induction of enhancement in B-photoreceptors was assessed by buffering intracellular Ca2+with the iontophoretic injection of BAPTA. Blocking light-elicited photoreceptor desensitization with BAPTA loading prior to applying 5-HT was used as an indication of the effectiveness of Ca2+buffering. Enhancement was blocked in preparations that received BAPTA loading prior to the application of 5-HT while typical enhancement was elicited by light and 5-HT in control preparations. These results indicate that enhancement involves a Ca2+-dependent process.