COMPLICATIONS AND SEQUELAE OF MENINGOCOCCAL INFECTIONS IN CHILDREN
COMPLICATIONS AND SEQUELAE OF MENINGOCOCCAL INFECTIONS IN CHILDREN
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DOI：
10.1016/s0022-3476(81)80250-8
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
BAKER, CJ
中科院分区：
文献类型：
--
作者：
EDWARDS, MS;BAKER, CJ
在1977-1979年间，对86例患有脑膜炎球菌性脑膜炎或菌血症的儿童进行了前瞻性评估，以确定并发症的发生率和预测其发展的特征。这些感染中大多数（83%）是由血清B组菌株引起的。幸存者中，27%经历了一种或更多化脓性、过敏或神经系统并发症。9%的儿童出现听力损失，在入院时出现白细胞增多或白细胞减少，或脑脊液白细胞增多1万/mm3的患者中，听力损失的发生率明显高于无并发症的患者（P < 0.01）。在幸存者中，10%出现过敏并发症，表现为皮肤血管炎或关节炎，发作于入院后5-8天。休克、紫癜性皮损和持续时间超过5天的发热在这些儿童中发生的频率明显高于发生听力损失或病程不复杂的儿童（P < 0.05）。过敏并发症在发病后14天内得到缓解。与脑膜炎奈瑟菌A组和C组相比，B组菌株似乎在与儿童感染相关的过敏性并发症方面处于中等水平。
Children (86) with meningococcal meningitis or bacteremia were evaluated prospectively between 1977-1979 to determine the incidence of complications and features predictive of their development. The majority (83%) of these infections were caused by serogroup B strains. The survivors, 27% experenced 1 or more suppurative, allergic or neurologic complications. Hearing loss, noted in 9% of children, occurred significantly more often in patients with admission leukocytosis or leukopenia, or with CSF leukocytosis > 10,000/mm3 than in those with an uncomplicated course (P < 0.01). Of the survivors, 10% developed allergic complications manifested as cutaneous vasculitis or arthritis with onset 5-8 days after admission. Shock, purpuric skin lesions and fever persisting longer than 5 days occurred significantly more often in these children than in those who developed hearing loss or those with an uncomplicated course (P < 0.05). Resolution of allergic complications occurred within 14 days of their onset. Compared to Neisseria mengitidis groups A and C, group B strains appear to be intermediate in their potential for allergic complications associated with childhood infection.