More acidic metabolites of Δ1‐tetrahydrocannabinol isolated from rabbit urine
More acidic metabolites of Δ1‐tetrahydrocannabinol isolated from rabbit urine
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从兔尿中分离出更多 Δ1-四氢大麻酚的酸性代谢物
DOI：
10.1111/j.2042-7158.1979.tb13486.x
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发表时间：
1979
影响因子：
3.3
通讯作者：
T. Ryman
中科院分区：
文献类型：
--
作者：
M. Nordqvist;S. Agurell;M. Rydberg;L. Falk;T. Ryman
在家兔体内进一步研究了Δ1‐四氢大麻酚（Δ1‐THC）在静脉给药后的体内代谢。从以前未研究过的尿液部分中分离出9种酸性代谢物，并通过气相色谱-质谱法和质子磁共振波谱法进行鉴定。主要代谢产物为侧链羟基化单羧酸。在异戊二烯部分的烯丙基位置羟基化的三个侧链单羧酸也被表征。代谢物4″‐hydroxy‐Δ1‐THC‐7‐oic酸和7‐hydroxy‐4”，5″‐bisnor‐Δ1‐THC‐3”‐oic酸迄今尚未鉴定。先前描述的二羧基代谢物高浓度存在。此外，O -葡糖苷是Δ1 - THC的体内尿代谢产物，这是第一次通过ms和p.m.r明确地确定。
The in vivo metabolism of Δ1‐trahydrocannabinol (Δ1‐THC) was further investigated in the rabbit after i.v. administration. Nine acidic metabolites were isolated from a previously not investigated fraction of the urine and identified by gas chromatography‐mass spectrometry and by proton magnetic resonance spectroscopy. The major metabolites were side‐chain hydroxylated monocarboxylic acids. Three side‐chain monocarboxylic acids hydroxylated in allylic positions in the isoprene moiety were also characterized. The metabolites 4″‐hydroxy‐Δ1‐THC‐7‐oic acid and 7‐hydroxy‐4”,5″‐bisnor‐Δ1‐THC‐3”‐oic acid were hitherto not identified. An earlier described dicarboxylic metabolite was present in high concentration. Further, the identity of an O‐glucuronide as an in vivo urinary metabolite of Δ1‐THC was here for the first time unambiguously established by m.s. and p.m.r.