Essential role of IPS-1 in innate immune responses against RNA viruses.
Essential role of IPS-1 in innate immune responses against RNA viruses.
复制标题
DOI：
10.1084/jem.20060792
复制
发表时间：
2006-07-10
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
IFN-β启动子刺激子(IPS)-1最近被确定为维甲酸诱导基因I （RIG-I）和黑色素瘤分化相关基因5 （Mda5）的适配器，它们识别不同的RNA病毒。在这里，我们展示了IPS-1在体内抗病毒反应中的关键作用。ips -1缺陷小鼠在RIG-I -和mda5介导的I型干扰素和炎性细胞因子诱导中均表现出严重缺陷，并且易受RNA病毒感染。RNA病毒诱导的干扰素调节因子-3和核因子κB的激活也在ips -1缺陷细胞中受损。然而，对于DNA病毒或双链B-DNA的应答，IPS-1都不是必需的。因此，IPS-1是rig -1和Mda5信号通路中唯一的适配器，介导对多种RNA病毒的有效应答。
IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses in vivo. IPS-1–deficient mice showed severe defects in both RIG-I– and Mda5-mediated induction of type I interferon and inflammatory cytokines and were susceptible to RNA virus infection. RNA virus–induced interferon regulatory factor-3 and nuclear factor κB activation was also impaired in IPS-1–deficient cells. IPS-1, however, was not essential for the responses to either DNA virus or double-stranded B-DNA. Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses.