Influence of nicotine on positive affect in anhedonic smokers
Influence of nicotine on positive affect in anhedonic smokers
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DOI：
10.1007/s00213-006-0688-5
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发表时间：
2007-05-01
影响因子：
3.4
通讯作者：
McChargue, Dennis
中科院分区：
文献类型：
--
作者：
Cook, Jessica Werth;Spring, Bonnie;McChargue, Dennis
理由：个人服用尼古丁以自我调节持续性负面影响的可能性，作为情感脆弱吸烟者高患病率的一种可能解释，受到了关注。然而，相对被忽视的是，吸烟者也可能自我管理尼古丁，以提高低positive affect. ObjectiveThis研究的可能性，尼古丁管理是否增加了快感缺乏的吸烟者的积极情感反应，积极的情绪induction.Materials和方法50经常吸烟者（50%女性）进行了两个积极的情绪诱导，在此期间，他们吸尼古丁或denicotinized香烟在平衡的顺序。结果随机效应回归分析显示，尼古丁与时间的交互作用使吸烟者产生了显著的快感缺失[t（181）=-2.01，p =0.04]，支持快感缺失调节尼古丁对积极情绪变化的影响的假设。简单效应分析显示，在高快感型吸烟者中存在显著的条件-时间交互作用[t（91）=2.47，p=0.01]，而在低快感型吸烟者中则无此交互作用[t（91）=0.34，p=0.73]。
Rationale The possibility that individuals administer nicotine to self-regulate persistent negative affect has received interest as a possible explanation for the high prevalence of affectively vulnerable smokers. Relatively overlooked, however, is the possibility that smokers might also self-administer nicotine to elevate low positive affect.Objectives This study examined whether nicotine administration augmented anhedonic smokers' positive affective response to a positive mood induction.Materials and methods Fifty regular smokers (50% female) underwent two positive mood inductions during which they smoked either a nicotinized or denicotinized cigarette in counterbalanced order. Positive affect was assessed before and at two time points after smoking.Results Random effects regression showed a significant anhedonia by condition-by-time interaction [t(181)=-2.01, p=0.04], supporting the hypothesis that anhedonia moderated nicotine's effect on changes in positive affect. Simple effect analyses showed a significant condition-by-time interaction among high anhedonic smokers [t(91)=2.47, p=0.01] but not among less anhedonic smokers [t(91)=0.34, p=0.73].Conclusion Smoking nicotine vs placebo heightened anhedonic smokers' ability to be induced into a positive mood, whereas nicotine had no effect on more hedonic smokers' positive mood.