Plasma total homocysteine level and bone mineral density - The Hordaland homocysteine study
Plasma total homocysteine level and bone mineral density - The Hordaland homocysteine study
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DOI：
10.1001/archinte.166.1.88
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发表时间：
2006-01-09
影响因子：
--
通讯作者：
Tell, GS
中科院分区：
文献类型：
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作者：
Gjesdal, CG;Vollset, SE;Tell, GS
背景：血浆总同型半胱氨酸(THcy)与髋部骨折有关，但与骨密度(BMD)无直接关系。我们研究了髋部骨密度与血浆总同型半胱氨酸、叶酸和维生素B水平以及亚甲基四氢叶酸还原酶(MTHFR)677C-GT和1298A-GT；C基因多态性的关系。方法：从1997年到2000年，从霍达兰同型半胱氨酸研究队列中测量了2268名男性和3070名女性的骨密度，年龄分别为47岁到50岁和71岁到75岁。低骨密度定义为各性别和年龄组中最低五分之一的骨密度。结果：中老年女性血浆tHcy水平与骨密度呈负相关(P=2.02 mg/L)，而低水平(9 mU/L[1.22 mg/L])tHcy水平女性为1.96(95%可信区间1.40~2.75)，男性差异无统计学意义。对血浆叶酸水平或钙和维生素D摄入量的额外调整并没有实质上改变结果。仅在女性中，血浆叶酸水平与BMD有关。我们没有观察到BMD与维生素B-12水平或MTHFR基因多态性之间的关系。结论：tHcy升高和叶酸水平降低与女性BMD降低有关，但与男性无关。这些发现表明，tHcy可能是女性骨质疏松症的一个潜在的可改变的危险因素。
Background: Plasma total homocysteine (tHcy) has been associated with hip fracture but not directly with bone mineral density (BMD). We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B, and the methylenetetrahydrofolate reductase (MTHFR) 677C -> T and 1298A -> C polymorphisms.Methods: Bone mineral density was measured between 1997 and 2000 in 2268 men and 3070 women, aged 47 to 50 and 71 to 75 years, from the Hordaland Homocysteine Study cohort. Low BMD was defined as BMD in the lowest quintile for each sex and age group. Linear, logistic, and generalized additive regression models were used.Results: Plasma levels of tHcy were inversely related to BMD among middle-aged and elderly women (P = 2.02 mg/L]) compared with low (< 9 mu mol/L [< 1.22 mg/L]) tHcy level was 1.96 (95% confidence interval, 1.40-2.75) for women and was not significant for men. Additional adjustments for plasma folate level or intake of calcium and vitamin D did not substantially alter the results. Plasma folate level was associated with BMD in women only. We observed no association between BMD and vitamin B-12 level or the MTHFR polymorphisms.Conclusions: Elevated tHcy and low folate levels were associated with reduced BMD in women but not in men. These findings suggest that tHcy may be a potential modifiable risk factor for osteoporosis in women.