Expression and localization of DLX3, PPARG and SP1 in bovine trophoblast during binucleated cell differentiation
Expression and localization of DLX3, PPARG and SP1 in bovine trophoblast during binucleated cell differentiation
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DOI：
10.1016/j.placenta.2011.08.014
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发表时间：
2011-11-01
期刊：
影响因子：
3.8
通讯作者：
Hue, I.
中科院分区：
文献类型：
--
作者：
Degrelle, S. A.;Murthi, P.;Hue, I.
在反刍动物中，滋养细胞的分化以形成双核细胞（BNC）为标志。它们从着床前开始出现，但其分化的分子机制仍未被广泛探索。利用我们最近的数据，我们分析了已知的早期胎盘形成调节因子DLX3和PPARG的表达模式，并将我们的分析扩展到它们的潜在调节因子之一SP1。我们的研究首次证实了DLX3、PPARG和SP1在牛BNC核中的共表达。这表明这些转录因子在胎盘前分化时可能通过BNC特异性基因发挥作用。(C) 2011 Elsevier Ltd.版权所有。
The differentiation of the trophoblast is marked in ruminants by the formation of binucleated cells (BNC). They appear from pre-implantation onwards but the molecular mechanisms underlying their differentiation remain largely unexplored. Taking advantage of our recent data, we analyzed the expression pattern of DLX3 and PPARG that are known regulators of early placenta formation and extended our analysis to one of their potential regulators, SP1. Our study is the first to demonstrate the co-expression of DLX3, PPARG and SP1 in bovine BNC nuclei. This suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation. (C) 2011 Elsevier Ltd. All rights reserved.