Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
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DOI：
10.3945/ajcn.114.101071
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发表时间：
2016-10-01
影响因子：
7.1
通讯作者：
Martorell, Reynaldo
中科院分区：
文献类型：
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作者：
Ramakrishnan, Usha;Gonzalez-Casanova, Ines;Martorell, Reynaldo
背景：二十二碳六烯酸（DHA）是大脑的重要组成部分。从精心设计的干预试验的长期效益增加DHA摄入量在pregnancy has sparsely.Objective：我们评估了全球的认知，行为，并在5岁的墨西哥妇女参加了产前DHA补充随机对照试验的后代注意力。设计：共有1094名妇女被随机分配到400毫克的DHA或安慰剂/天，从怀孕18至22周，直到分娩。我们使用麦卡锡儿童能力量表（MSCA）、儿童行为评估系统第二版（BASC-2）的父母量表和Conners儿童持续表现测试（K-CPT）评估了797名5岁（973例活产婴儿的82%）的后代的认知发育、行为和执行功能，包括注意力。我们比较了各组的原始评分、T评分和标准化评分（如适用）。我们通过家庭环境质量、母亲智力和社会经济地位来检验异质性。结果：两组间MSCA评分无差异（P > 0.05），但DHA组12个月时家庭环境对一般认知能力的积极影响较安慰剂组减弱（P-交互作用< 0.05）。两组之间在BASC-2上无差异。在K-CPT中，DHA组的后代与安慰剂组相比，在遗漏方面的平均+/- SD T评分有所改善（DHA：47.6 +/- 10.3;安慰剂：49.6 +/- 11.2; P < 0.01），无差异（P > 0.05）的其他K-CPT评分或比例谁是在临床上的危险注意缺陷多动障碍后Bonferroni校正多重比较。产前接触DHA可能有助于改善学龄前儿童的持续注意力。
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has been sparse.Objective: We evaluated global cognition, behavior, and attention at age 5 y in the offspring of Mexican women who participated in a randomized controlled trial of prenatal DHA supplementation.Design: A total of 1094 women were randomly assigned to receive 400 mg of either DHA or placebo/d from 18 to 22 wk of pregnancy until delivery. We assessed cognitive development and behavioral and executive functioning, including attention, in 797 offspring at age 5 y (82% of 973 live births) with the use of the McCarthy Scales of Children's Abilities (MSCA), the parental scale of the Behavioral Assessment System for Children, Second Edition (BASC-2), and the Conners' Kiddie Continuous Performance Test (K-CPT). We compared the groups on raw scores, T-scores, and standardized scores, as appropriate. We examined heterogeneity by the quality of the home environment, maternal intelligence, and socioeconomic status.Results: There were no group differences for MSCA scores (P > 0.05), but the positive effect of the home environment at 12 mo on general cognitive abilities was attenuated in the DHA group compared with in the placebo group (P-interaction < 0.05). There were no differences between groups on the BASC-2. On the K-CPT, offspring in the DHA group showed improved mean +/- SD T-scores compared with those of the placebo group for omissions (DHA: 47.6 +/- 10.3; placebo: 49.6 +/- 11.2; P < 0.01) with no differences (P > 0.05) for the other K-CPT scores or of the proportion who were clinically at risk of attention deficit hyperactivity disorders after Bonferroni correction for multiple comparisons.Conclusion: Prenatal exposure to DHA may contribute to improved sustained attention in preschool children.