Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex
Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex
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DOI：
10.1111/j.1476-5381.2009.00175.x
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发表时间：
2009-06
影响因子：
7.3
通讯作者：
Satoshi Yamamura;Keiko Ohoyama;Tatsuya Hamaguchi;Masanori Nakagawa;Dai Suzuki;Takuya Matsumoto;E. Motomura;H. Tanii;T. Shiroyama;M. Okada
中科院分区：
文献类型：
--
作者：
Satoshi Yamamura;Keiko Ohoyama;Tatsuya Hamaguchi;Masanori Nakagawa;Dai Suzuki;Takuya Matsumoto;E. Motomura;H. Tanii;T. Shiroyama;M. Okada
背景与目的：非典型抗精神病药佐替平治疗精神分裂症和急性躁狂症有效，但治疗期间癫痫发作的发生率高于其他抗精神病药。此外，佐替平临床作用的机制仍不清楚。
Background and purpose: The atypical antipsychotic drug, zotepine, is effective in treatment of schizophrenia and acute mania, but the incidence of seizures during treatment is higher than with other antipsychotics. In addition, the mechanisms underlying the clinical actions of zotepine remain uncharacterized.