Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1
Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1
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DOI：
10.1086/515654
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发表时间：
1998-10-01
影响因子：
6.4
通讯作者：
Kreiss, J
中科院分区：
文献类型：
--
作者：
Martin, HL;Nyange, PM;Kreiss, J
为探讨避孕方法、性传播疾病（STD）和HIV-1感染之间的关系，在肯尼亚蒙巴萨市一家性病门诊就诊的女性性工作者中进行了一项前瞻性观察性队列研究。与HIV-1感染显著相关的人口统计学和行为因素包括工作场所类型、安全套使用和产次。在多变量模型中，外阴炎、生殖器溃疡病、阴道分泌物和念珠菌性阴道炎与HIV-1血清转换显著相关。使用醋酸甲羟孕酮（DMPA）的妇女HIV-1感染的发生率增加（风险比[HR]，2.2; 95%置信区间[CI]，1.4-3.4）。在控制人口统计学和暴露变量以及生物学协变量的多变量模型中，DMPA使用者中HIV-1感染的校正HR为2.0（CI，1.3-3.1），使用高剂量口服避孕药与HIV-1感染之间存在相关趋势（HR，2.6; CI，0.8-8.5）。
To examine associations between method of contraception, sexually transmitted diseases (STDs), and incident human immunodeficiency virus type 1 (HIV-1) infection, a prospective observational cohort study was done among female sex workers attending a municipal STD clinic in Mombasa, Kenya, Demographic and behavioral factors significantly associated with HIV-1 infection included type of workplace, condom use, and parity. In multivariate models, vulvitis, genital ulcer disease, vaginal discharge, and Candida vaginitis were significantly associated with HIV-1 seroconversion. Women who used depo medroxyprogesterone acetate (DMPA) had an increased incidence of HIV-1 infection (hazard ratio [HR], 2.2; 95% confidence interval [CI], 1.4-3.4). In a multivariate model controlling for demographic and exposure variables and biologic covariates, the adjusted HR for HIV-1 infection among DMPA users was 2.0 (CI, 1.3-3.1), There was a trend for an association between use of high-dose oral contraceptive pills and HIV-1 acquisition (HR, 2.6; CI, 0.8-8.5).