Decline of immune responsiveness: A pathogenetic factor in Alzheimer's disease?
Decline of immune responsiveness: A pathogenetic factor in Alzheimer's disease?
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DOI：
10.1016/j.jpsychires.2004.12.005
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发表时间：
2005-09-01
影响因子：
4.8
通讯作者：
Schott, K
中科院分区：
文献类型：
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作者：
Richartz, E;Stransky, E;Schott, K
免疫学改变在阿尔茨海默病(AD)发病机制中的作用被广泛讨论。到目前为止，关于全身免疫学变化的研究结果并不一致。我们测定了20例阿尔茨海默病患者和21例正常对照组脑脊液和血清中促炎症细胞因子IL-1β、IL-2、IL-6和肿瘤坏死因子-α，以及可溶性受体sIL-2R、sIL-6R和sTNF-αr的浓度。此外，我们还研究了27例AD患者和25例对照组刺激的血细胞培养中促炎症的IL-6、IL-12、干扰素-γ和肿瘤坏死因子-α的水平，以及抗炎的IL-5和IL-13的水平。AD患者脑脊液和血清中的含量降低或低于检测下限。在有丝分裂原刺激的血培养中，我们发现AD组促炎和抗炎细胞因子显着减少。我们的数据表明，AD患者的免疫反应性普遍下降。根据最近的研究，免疫反应受损可能被认为是阿尔茨海默病的发病相关因素。关于衰老在AD中的假定作用，我们假设过早的免疫衰老有助于阿尔茨海默氏病的病理。(C)2005爱思唯尔有限公司。保留所有权利。
The involvement of immunological alterations in the pathogenesis of Alzheimer's disease (AD) is widely discussed. Hitherto, findings on systemic immunological alterations are inconsistent. We measured the concentrations of the pro-inflammatory cytokines IL-1 beta, IL-2, IL-6, and TNF-alpha, and of the soluble receptors sIL-2r, sIL-6r, and sTNF-alpha r, in cerebrospinal fluid (CSF) and serum of 20 Alzheimer patients and 21 controls. Moreover, we studied levels of the pro-inflammatory IL-6, Il-12, IFN-gamma, and TNF-alpha, and of the anti-inflammatory IL-5 and IL-13 in stimulated blood cell cultures from 27 AD patients and 25 controls. The levels in CSF and serum were diminished in AD or under detection limit. In mitogen-stimulated blood cultures we found a significant decrease of pro- and anti-inflammatory cytokines in the AD group. Our data suggest a general decline of immune responsiveness in AD. Based on the recent research, an impaired immune response may be considered as a pathogenetically relevant factor in AD. With respect to the putative role of ageing in AD, we assume a premature immunosenescence contributing to the Alzheimer's pathology. (c) 2005 Elsevier Ltd. All rights reserved.