Effect of preoperative pulse oximeter oxygen saturation on postoperative prolonged mechanical ventilation in patients with tetralogy of Fallot.
Effect of preoperative pulse oximeter oxygen saturation on postoperative prolonged mechanical ventilation in patients with tetralogy of Fallot.
复制标题
术前脉搏血氧饱和度对法洛四联症患者术后长时间机械通气的影响
DOI：
10.3389/fcvm.2022.967240
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发表时间：
2022
影响因子：
3.6
通讯作者：
Yan, Fuxia
中科院分区：
文献类型：
--
作者：
Wu, Xie;An, Ran;Luo, Qipeng;Li, Yinan;Wang, Hongbai;Liu, Qiao;Huang, Jiangshan;Jia, Yuan;Yuan, Su;Yan, Fuxia
关键词：
术前脉搏血氧饱和度（SpO2）作为一种易于获取和干预的临床指标，是影响法洛四联症（TOF）患者预后的重要因素。然而，SpO2是否与术后机械通气（MV）时间相关仍不清楚。因此，本研究旨在研究术前SpO2对TOF儿童术后长时间机械通气（PMV）的影响。该研究包括2016年1月至2018年12月在中国阜外医院接受TOF矫正手术的18岁以下儿童。采用单因素和多因素Logistic回归分析评价术前SpO2对术后PMV的影响。在确定SpO2为PMV的独立危险因素后，根据SpO2的临界值将患者进一步分为两组，并使用倾向评分匹配（PSM）分析来消除混杂因素的影响。采用逻辑回归方法比较PSM后两组的结局。最终共有617例患者入组本研究。通过单因素和多因素Logistic分析，确定了4个PMV的独立危险因素，即SpO2、手术技术、主动脉阻断时间和术中最低温度。根据219例配对患者PSM后的结局，术前SpO2较低的患者PMV的发生率显著较高（P = 0.022）。此外，在较低的术前SpO2水平下，机械通气时间（P = 0.019）、重症监护室住院时间（P = 0.044）、术后住院时间（P = 0.006）、住院时间（P = 0.039）和住院费用（P = 0.019）显著增加。术前低SpO2是TOF儿童术后PMV的独立危险因素。
As an easily accessible and intervened clinical indicator, preoperative pulse oximeter oxygen saturation (SpO2) is an important factor affecting the prognosis of patients with tetralogy of Fallot (TOF). However, whether SpO2 is associated with postoperative mechanical ventilation (MV) time remains unknown. Therefore, this study aimed to investigate the impact of preoperative SpO2 on postoperative prolonged mechanical ventilation (PMV) in children with TOF. The study included children younger than 18 years who underwent corrective operations for TOF between January 2016 and December 2018 in Fuwai Hospital, China. Univariate and multivariate logistic regression analyses were used to evaluate the influence of preoperative SpO2 on postoperative PMV. After identifying SpO2 as an independent risk factor for PMV, patients were further divided into two groups according to the cutoff value of SpO2, and propensity score matching (PSM) analysis was used to eliminate the effect of confounding factors. The logistic regression was used to compare the outcomes between the two groups after PSM. A total of 617 patients were finally enrolled in this study. By the univariable and multivariate logistic analysis, four independent risk factors for PMV were determined, namely, SpO2, surgical technique, aortic cross-clamp time, and intraoperative minimum temperature. According to the outcomes of 219 paired patients after PSM, the incidence of PMV was significantly higher in patients with lower preoperative SpO2 (P = 0.022). Also, there was significant increase in mechanical ventilation time (P = 0.019), length of intensive care unit stay (P = 0.044), postoperative hospital stay (P = 0.006), hospital stay (P = 0.039), and hospitalization cost (P = 0.019) at the lower preoperative SpO2 level. Low preoperative SpO2 represents an independent risk factor of postoperative PMV in children with TOF.
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影响因子：
5.8
作者：
Agouridakis P;Kyriakou D;Alexandrakis MG;Prekates A;Perisinakis K;Karkavitsas N;Bouros D
通讯作者：
Bouros D
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影响因子：
5.3
作者：
Ma, Jing;Chen, Shiyu;Huang, Guoying
通讯作者：
Huang, Guoying
影响因子：
3.8
作者：
Koski, Tapio;Salmi, Heli;Keski-Nisula, Juho;Bille, Anders;Bjornsson, Einar;Jessen, Casper;Forstholm, Ronnie;Laaperi, Mitja;Rautiainen, Paula
通讯作者：
Rautiainen, Paula
影响因子：
2.8
作者：
Sanfilippo F;Palumbo GJ;Bignami E;Pavesi M;Ranucci M;Scolletta S;Pelosi P;Astuto M
通讯作者：
Astuto M
影响因子：
1.7
作者：
Zabala, Luis M.;Guzzetta, Nina A.
通讯作者：
Guzzetta, Nina A.