Perinatal low-fat dietary intervention affects glucose metabolism in female adult and aging offspring
Perinatal low-fat dietary intervention affects glucose metabolism in female adult and aging offspring
复制标题
围产期低脂饮食干预影响成年女性和老龄后代的葡萄糖代谢
DOI：
10.1111/ggi.14378
复制
发表时间：
2022
影响因子：
3.3
通讯作者：
Mogi M
中科院分区：
文献类型：
--
作者：
Ueno M;Liu S;Kiyoi T;Sugiyama T;Mogi M
目的糖尿病使女性在晚年健康状况不佳的风险很高。本研究以健康与疾病发育起源理论为基础，探讨围产期限脂对母鼠高脂饮食诱导的母体肥胖模型(HFD小鼠)在成年后至晚年维持血糖稳态的作用。监测生理代谢参数，包括体重和血清总胆固醇和甘油三酯水平。对12周龄和70周龄的仔鼠进行糖耐量试验和胰岛素敏感性试验。结果HFD可引起仔鼠异常体重增加、高脂血症及糖耐量和胰岛素敏感性降低。断奶后的标准饮食摄入量改善了70周龄后代的体重增加、血清总胆固醇水平和葡萄糖耐量，但不能改善胰岛素敏感性。只有在孕期和哺乳期限制围产期脂肪摄入，然后进行终生标准食物摄入量，才能有效恢复老年女性后代的胰岛素敏感性。结论围产期低脂干预可预防糖代谢恶化。为了改善女性一生中的健康状况，在发育早期进行适当的营养干预可能会重置疾病轨迹，防止糖尿病的发生和发展。Geriatr Gerontol Int 2022；22：441-448。
AimDiabetes confers a high risk of developing poor health in later life in women. Based on the Developmental Origins of Health and Disease theory, the present study was undertaken to investigate the efficacy of perinatal fat restriction in maternal high‐fat‐exposed female offspring to maintain glucose homeostasis in later life between adulthood and aging.MethodsLow‐fat dietary intervention during either gestation or lactation was performed using a high‐fat diet‐induced maternal obesity mouse model (HFD mice). Physiological metabolic parameters, including body weight and serum levels of total cholesterol and triglycerides, were monitored. Glucose tolerance test and insulin sensitivity test were performed in 12‐ and 70‐week‐old offspring. Insulin‐positive islet cells were also observed using immunohistochemical staining.ResultsHFD significantly induced abnormal weight gain, hyperlipidemia and impairment of both glucose tolerance and insulin sensitivity in offspring. Standard diet intake after weaning improved weight gain, serum total cholesterol level and glucose tolerance, but not insulin sensitivity, in 70‐week‐old offspring. Only perinatal fat restriction during both gestation and lactation, followed by standard food intake for the rest of their life, provided adequate efficacy to restore insulin sensitivity in aging female progeny.ConclusionsPerinatal low‐fat intervention may prevent deterioration of glucose metabolism. To improve the health status over a female's lifespan, appropriate nutritional intervention during the early developmental stage may reset the disease trajectory and prevent the onset and development of diabetes.Geriatr Gerontol Int 2022; 22: 441–448.