Sildenafil improves endothelial function in patients with pulmonary hypertension
Sildenafil improves endothelial function in patients with pulmonary hypertension
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DOI：
10.1016/j.pupt.2007.01.008
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Modena, Maria Grazia
中科院分区：
文献类型：
--
作者：
Rossi, Rosario;Nuzzo, Annachiara;Modena, Maria Grazia
背景：西地那非已被证明可有效治疗肺动脉高压，并对内皮功能有良好的影响。我们的假设是，西地那非对肺动脉高压患者的部分有益作用是由于内皮功能的改善。方法：9 名血栓栓塞性肺动脉高压患者（7 名女性，年龄 67+/-9 岁）接受西地那非治疗，平均剂量为 150+/-75mg/die。在基线和 6 个月后，所有患者均接受：右心导管插入术、6 分钟步行距离和内皮功能研究，包括测量肱动脉血流介导的血管舒张，以及血浆内皮素-1 和血管性血友病因子水平的剂量。 结果：在随访期间，我们发现平均肺动脉压和小动脉阻力显着降低。因此，功能能力得到改善（平均为 + 37 m）。西地那非改善内皮依赖性血管舒张并降低内皮素-1 血浆浓度（从 4.5 +/- 0.6 至 3.1 +/- 0.7pg/mL；p
Background: Sildenafil has been shown to be effective in the treatment of pulmonary hypertension, and has favourable effects on endothelial function. Our hypothesis is that a part of the beneficial effects of sildenafil in patients with pulmonary hypertension is due to the improvement of the endothelial function.Methods: Nine patients (seven females, age 67 +/- 9 years) with thromboembolic Pulmonary hypertension were treated with sildenafil, at a mean dose of 150 +/- 75mg/die. At baseline and after 6 months all patients underwent: right-heart catheterization, 6-min walking distance, and a study of endothelial function, including the measure of the flow-mediated vasodilation of the brachial artery, and the dosage of plasma levels of endothelin-l and von Willebrand factor.Results: During follow-up We found a significant reduction of mean pulmonary artery pressure and arteriolar resistances. Accordingly, the functional capacity improved (ail average of + 37 m). Sildenafil improved endothelial-dependent vasodilation and reduced plasma concentrations of endothelin-1 (from 4.5 +/- 0.6 to 3.1 +/- 0.7pg/mL; p