A Mediterranean dietary intervention in healthy American women changes plasma carotenoids and fatty acids in distinct clusters
A Mediterranean dietary intervention in healthy American women changes plasma carotenoids and fatty acids in distinct clusters
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DOI：
10.1016/j.nutres.2009.03.001
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发表时间：
2009-03-01
影响因子：
4.5
通讯作者：
Sen, Ananda
中科院分区：
文献类型：
--
作者：
Djuric, Zora;Ren, Jianwei;Sen, Ananda
这项研究调查了血浆脂肪酸和类胡萝卜素的变化模式时，妇女被要求遵循一种新的，希腊-地中海交换名单饮食。共有69名年龄在25至59岁之间的健康非肥胖女性被随机分为两组，一组继续自己的日常饮食，另一组遵循改良的地中海饮食，为期6个月。血脂、三酰甘油、胰岛素、葡萄糖或C反应蛋白无显著变化。平均血浆类胡萝卜素增加了55%，这与水果和蔬菜消费量的大幅增加一致。同样，脂肪摄入量的变化反映在血液脂肪酸中，平均血浆单不饱和脂肪酸增加25%。主成分分析进行了检查类胡萝卜素和脂肪酸水平的变化的个体间变异的来源。地中海饮食的变化聚集在4个组分中，占血浆水平变化的78%。血浆中叶黄素、α-胡萝卜素和β-胡萝卜素的增加以“蔬菜”模式聚集在一起，水果中发现的类胡萝卜素、β-隐黄质和玉米黄质的增加也聚集在一起，但占的方差较小。血浆单不饱和脂肪酸的增加与血浆多不饱和脂肪酸的减少聚集在一起，这与所消耗的油类型的替代一致。脂肪酸水平与类胡萝卜素的唯一关联是番茄红素，它与饱和脂肪酸的增加聚集在一起。血液水平的变化表明，交换清单饮食对使用美国现有食物的地中海营养摄入量是有效的。(c)2009爱思唯尔公司All rights reserved.
This study examined patterns of changes in plasma fatty acids and carotenoids when women were asked to follow a novel, Greek-Mediterranean exchange list diet. A total of 69 healthy, nonobese women ages 25 to 59 years were randomized either to continue their own usual diet or to follow a modified Mediterranean diet for 6 months. There were no significant changes in blood lipids, triacylglycerol, insulin, glucose, or C-reactive protein. Mean plasma carotenoids increased by 55%, which is consistent with a large increase in fruit and vegetable consumption. Likewise, changes in fat intakes were reflected in blood fatty acids, with a 25% increase in mean plasma monounsaturated fatty acids. Principal component analysis was conducted to examine the sources of interindividual variation for changes in carotenoid and fatty acid levels. Changes in the Mediterranean diet were clustered together in 4 components that accounted for 78% of the variance in plasma levels. Increases in plasma lutein, a-carotene, and beta-carotene clustered together in a "vegetable" pattern, and increases in carotenoids found in fruit, beta-cryptoxanthin and zeaxanthin also clustered together but accounted for less of the variance. Increases in plasma monounsaturated fatty acids were clustered with a decrease in plasma polyunsaturated fatty acids, consistent with substitution in the type of oils consumed. The only association of fatty acid levels with carotenoids was that of lycopene, which clustered together with an increase in saturated fatty acids. The changes in blood levels indicate the exchange list diet was effective for targeting Mediterranean nutrient intakes using foods available in the United States. (c) 2009 Elsevier Inc. All rights reserved.