Exercise and MEF2-HDAC interactions
Exercise and MEF2-HDAC interactions
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DOI：
10.1139/h07-082
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发表时间：
2007-10-01
影响因子：
3.4
通讯作者：
McGee, Sean L.
中科院分区：
文献类型：
--
作者：
McGee, Sean L.
运动增加骨骼肌的代谢能力，从而改善全身能量平衡，并有助于运动的积极健康益处。这在一定程度上是由许多代谢酶的表达增加介导的，这些代谢酶主要在转录水平上受到调节。在分子水平上，这些基因中的许多基因通过与肌细胞增强因子2转录因子的相互作用由转录抑制因子的11类组蛋白脱乙酰酶（HDAC）家族（特别是HDAC 5）调节。HDAC 5激酶，包括5 '-AMP活化蛋白激酶和蛋白激酶D，似乎通过灭活HDAC 5和诱导HDAC 5核输出来调节骨骼肌代谢基因转录。这些机制似乎参与运动诱导的基因表达，并可能是重要的骨骼肌适应运动。
Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class 11 histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5'-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.