Intestinal microbiome and lymphoma development.
Intestinal microbiome and lymphoma development.
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肠道微生物组和淋巴瘤的发展。
DOI：
10.1097/ppo.0000000000000047
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Schiestl,RobertH
中科院分区：
文献类型：
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作者：
Yamamoto,MitsukoL;Schiestl,RobertH
肠道微生物群和肠道免疫系统必须进行沟通，以维持耐受性和激活之间的平衡。我们的免疫系统保护我们免受病原微生物的侵害，同时我们的身体还寄生着数万亿微生物、共生体、互利共生体以及一些对人类健康至关重要的微生物。由于免疫系统和肠道微生物群之间存在如此密切的相互作用，因此一些淋巴瘤（例如粘膜相关淋巴组织淋巴瘤）被证明是由某些细菌的存在引起的也就不足为奇了。动物模型在阐明细菌诱导的粘膜相关淋巴组织淋巴瘤的病因和建立机制方面发挥了重要作用。在这篇综述中，我们讨论了应用动物模型研究肠道微生物群与淋巴瘤之间联系的不同方法，并有助于揭示微生物群诱发淋巴瘤的机制。尽管已发表的研究很少证明微生物群与淋巴瘤发展之间的相互作用，但我们相信这种联系是真实的，并且可以在未来利用它来增强我们对因果关系的理解并改善淋巴瘤的预后和治疗。
The intestinal microbiota and gut immune system must communicate to maintain a balance between tolerance and activation. Our immune system protects us from pathogenic microbes at the same time that our bodies are host to trillions of microbes, symbionts, mutualists, and some that are essential to human health. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosal-associated lymphoid tissue lymphoma have been shown to be caused by the presence of certain bacteria. Animal models have played an important role in elucidating the causation and establishing the mechanism of bacteria-induced mucosal-associated lymphoid tissue lymphoma. In this review, we discuss different ways that animal models have been applied to investigate links between the gut microbiota and lymphoma and have helped to reveal the mechanisms of microbiota-induced lymphoma. Although there is a paucity of published studies demonstrating the interplay between the microbiota and lymphoma development, we believe that the connection is real and that it can be exploited in the future to enhance our understanding of causation and to improve the prognosis and treatment of lymphoma.