Adipose tissue fatty acid metabolism in insulin-resistant men
Adipose tissue fatty acid metabolism in insulin-resistant men
复制标题
DOI：
10.1007/s00125-008-1040-x
复制
发表时间：
2008-08-01
期刊：
影响因子：
8.2
通讯作者：
Frayn, K. N.
中科院分区：
文献类型：
--
作者：
Bickerton, A. S. T.;Roberts, R.;Frayn, K. N.
目的/假设增加NEFA的生产和浓度可能是胰岛素抵抗的基础。我们检测了胰岛素抵抗超重男性（BM 1 25-35 kg/m2）的全身和脂肪组织NEFA代谢。方法在一项队列研究中，我们检测了空腹胰岛素水平在上四分位数的男性（n = 124）和空腹胰岛素水平低于中位数的男性（n = 159）的NEFA浓度。在一项代谢研究中，我们研究了NEFA代谢的空腹和餐后状态，在10个胰岛素抵抗的男性和10个controls.Results在队列研究中，空腹NEFA浓度没有显着差异的两组（中位数值：胰岛素抵抗的男性，410 μ mol/L;控制，445 2 μ mol/L）。然而，三酰甘油浓度差异显著（分别为1.84和1.18 mmol/l，p
Aims/hypothesis Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant overweight men (BM1 25-35 kg/m(2)).Methods In a cohort study we examined NEFA concentrations in men in the upper quartile of fasting insulin (n = 124) and in men with fasting insulin below the median (n 159). In a metabolic study we examined NEFA metabolism in the fasting and postprandial states, in ten insulin-resistant men and ten controls.Results In the cohort study, fasting NEFA concentrations were not significantly different between the two groups (median values: insulin-resistant men, 410 mu mol/l; controls, 445 2 mu mol/l). However, triacylglycerol concentrations differed markedly (1.84 vs 1.18 mmol/l respectively, p