4D Flow MRI Estimation of Boundary Conditions for Patient Specific Cardiovascular Simulation
4D Flow MRI Estimation of Boundary Conditions for Patient Specific Cardiovascular Simulation
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DOI：
10.1007/s10439-019-02285-2
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发表时间：
2019-08-01
影响因子：
3.8
通讯作者：
Roldan-Alzate, Alejandro
中科院分区：
文献类型：
--
作者：
Pewowaruk, Ryan;Roldan-Alzate, Alejandro
基于精确图像的心血管模拟需要患者特定的入口、出口和血管壁机械特性的边界条件 (BC)。虽然入口 BC 通常是无创确定的，但有创压力导管插入术通常用于确定患者特定的出口 BC 和血管壁机械特性。提出了一种使用 4D Flow MRI 无创确定患者特定出口 BC 和血管壁机械特性的方法，并提出了使用乳胶管进行体外验证和体内肺动脉狭窄 (PAS) 支架干预的结果。对于体外验证，使用 4D Flow MRI 的 BC 进行的模拟与台式测量之间存在可接受的一致性。对于 PAS 虚拟干预，模拟可以正确预测血流分布，与 MRI 相比，误差为 9%。使用 4D Flow MRI 无创地确定患者特定的 BC 提高了使用基于图像的模拟的能力，因为并不总是进行压力导管插入术。
Accurate image based cardiovascular simulations require patient specific boundary conditions (BCs) for inlets, outlets and vessel wall mechanical properties. While inlet BCs are typically determined non-invasively, invasive pressure catheterization is often used to determine patient specific outlet BCs and vessel wall mechanical properties. A method using 4D Flow MRI to non-invasively determine both patient specific outlet BCs and vessel wall mechanical properties is presented and results for both in vitro validation with a latex tube and an in vivo pulmonary artery stenosis (PAS) stent intervention are presented. For in vitro validation, acceptable agreement is found between simulation using BCs from 4D Flow MRI and benchtop measurements. For the PAS virtual intervention, simulation correctly predicts flow distribution with 9% error compared to MRI. Using 4D Flow MRI to noninvasively determine patient specific BCs increases the ability to use image based simulations as pressure catheterization is not always performed.