Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population
Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population
复制标题
ALOX15基因多态性与中国北方汉族人群缺血性脑卒中的相关性
DOI：
10.1007/s12031-012-9721-9
复制
发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Lei Li
中科院分区：
文献类型：
--
作者：
Jie Zhao;Zhiyi He;Shanshan Ma;Lei Li
花生四烯酸12/15-脂氧合酶（12/15-LOX）是脂质过氧化酶家族的成员，在动脉粥样硬化中起主要作用。本研究旨在探讨ALOX 15基因多态性是否与中国北方汉族人群缺血性脑卒中有关。病例对照研究的参与者包括396例缺血性卒中患者（239例男性，157例女性）和360例健康受试者（211例男性，149例女性）。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析ALOX 15基因rs7217186多态性，采用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）分析ALOX 15基因rs 2619112多态性。rs7217186的CC基因型和C等位基因的频率在缺血性卒中患者中高于对照组[男性P= 0.014，动脉粥样硬化性缺血性卒中（ACI）患者P= 0.007]。缺血性脑卒中患者rs 2619112的AA基因型和A等位基因频率高于对照组（男性P= 0.011，ACI患者P= 0.015）。多因素Logistic回归分析显示，rs7217186和rs 2619112在男性和ACI中调整混杂因素后具有显著性。ALOX 15基因rs7217186和rs 2619112多态性与中国北方汉族男性和ACI患者缺血性脑卒中相关。
Arachidonate 12/15-lipoxygenase (12/15-LOX) is a member of the lipid peroxidizing enzyme family and plays a major role in atherosclerosis. The present study aimed to evaluate whether or not theALOX15gene polymorphism is involved in ischemic stroke in northern Chinese Han population. Participants in a case–control study included 396 patients (239 males, 157 females) with ischemic stroke and 360 healthy subjects (211 males, 149 females). The rs7217186 polymorphism of theALOX15gene was analyzed by polymerase chain reaction and restriction fragment length polymorphism, while the rs2619112 polymorphism of theALOX15gene was analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The frequencies of the CC genotype and the C allele of rs7217186 were higher in participants with ischemic stroke than in the control group [P= 0.014 in males,P= 0.007 in atherosclerosis ischemic stroke (ACI)]. The frequencies of the AA genotype and the A allele of rs2619112 were higher in participants with ischemic stroke than in the control group (P= 0.011 in males,P= 0.015 in ACI). Multiple logistic regression analysis revealed the significance of rs7217186 and rs2619112 in males and in ACI after adjustment for confounding factors. The rs7217186 and rs2619112 polymorphisms of theALOX15gene were associated with ischemic stroke in males and in patients with ACI in northern Chinese Han population.
登录
查看更多内容
影响因子：
13.6
作者：
Dobrian, Anca D.;Lieb, David C.;Cole, Banumathi K.;Taylor-Fishwick, David A.;Chakrabarti, Swarup K.;Nadler, Jerry L.
通讯作者：
Nadler, Jerry L.
影响因子：
3.9
作者：
J. Wittwer;Jacqueline Marti‐Jaun;M. Hersberger
通讯作者：
J. Wittwer;Jacqueline Marti‐Jaun;M. Hersberger
DOI：
10.1515/cclm.2007.103
发表时间：
2007
期刊：
2008 IEEE Conference on Computer Vision and Pattern Recognition
影响因子：
--
作者：
J. Wittwer;Mathias Bayer;A. Mosandl;J. Muntwyler;M. Hersberger
通讯作者：
J. Wittwer;Mathias Bayer;A. Mosandl;J. Muntwyler;M. Hersberger
影响因子：
5.3
作者：
Assimes, Thernistocles L.;Knowles, Joshua W.;Quertermous, Thomas
通讯作者：
Quertermous, Thomas
影响因子：
5.3
作者：
McCaskie, Pamela A.;Beilby, John P.;Palmer, Lyle J.
通讯作者：
Palmer, Lyle J.