Ageing: definitions, mechanisms and the magnitude of the problem
Ageing: definitions, mechanisms and the magnitude of the problem
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DOI：
10.1053/bega.2001.0244
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发表时间：
2001-12-01
影响因子：
3.2
通讯作者：
Sinclair, A
中科院分区：
文献类型：
--
作者：
Balcombe, NR;Sinclair, A
所有的多细胞生物都会随着时间而变化。受孕预示着生长和发育的开始，导致物种的繁殖能力和繁殖。随着时间的推移，生物体老化，最终导致死亡。虽然我们对生长和繁殖的知识和定义已经牢固确立，但对老龄化的概念仍然不太了解。对老龄化缺乏单一定义的原因之一是，可以根据社会、行为、生理、形态、细胞和分子的变化，以许多不同的方式来考虑老龄化。研究已经提出了许多理论，可以解释衰老过程。在本章中，我们将回顾其中的一些理论，并解决以下一些基本问题：什么是衰老？如何衡量衰老？衰老开始是什么时候？什么时候一个生物体被定义为老的？
All multi-cellular organisms undergo change with time. Conception heralds the onset of growth and development, leading to reproductive competence and propagation of the species. With time, organisms age, leading to death as a final end-point. Whilst our knowledge and definitions of growth and reproduction are firmly established, the concept of ageing remains less well understood. One of the reasons for the lack of a singular definition of ageing is that it can be considered in many different ways, according to social, behavioural, physiological, morphological, cellular and molecular changes. Research has led to a number of theories being proposed that may explain the ageing process. In this chapter, we will review some of these theories and address some of the following fundamental questions: What is ageing? How can ageing be measured? When does ageing begin? When is an organism defined as old?.