The basic principles of chimeric antigen receptor design.
The basic principles of chimeric antigen receptor design.
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DOI：
10.1158/2159-8290.cd-12-0548
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发表时间：
2013-04
期刊：
影响因子：
28.2
通讯作者：
Rivière I
中科院分区：
文献类型：
--
作者：
Sadelain M;Brentjens R;Rivière I
汽车是提供抗原结合和T细胞活化功能的重组受体。在过去的十年中，已经报道了许多汽车，靶向一系列细胞表面肿瘤抗原。它们的生物学功能在引入包含共刺激结构域的三方受体（称为第二代汽车）后发生了显著变化。这些最近已经在用CD19靶向自体T细胞治疗的患者中证明了临床益处。汽车可以与共刺激配体、嵌合共刺激受体或细胞因子组合以进一步增强T细胞效力、特异性和安全性。汽车代表了一类新的药物，具有令人兴奋的癌症免疫治疗潜力。
CARs are recombinant receptors that provide both antigen-binding and T cell activating functions. A multitude of CARs has been reported over the past decade, targeting an array of cell surface tumor antigens. Their biological functions have dramatically changed following the introduction of tri-partite receptors comprising a costimulatory domain, termed second generation CARs. These have recently demonstrated clinical benefit in patients treated with CD19-targeted autologous T cells. CARs may be combined with costimulatory ligands, chimeric costimulatory receptors or cytokines to further enhance T cell potency, specificity and safety. CARs represent a new class of drugs with exciting potential for cancer immunotherapy.