Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease.
Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease.
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DOI：
10.3390/kidneydial2010013
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Nowak K
中科院分区：
文献类型：
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作者：
Steele C;Nowak K
肥胖症仍然是全世界工业化国家日益增长的公共卫生问题。在慢性肾病患者中，肥胖症的患病率也持续上升。流行病学数据表明，那些超重和肥胖的人，通过身体质量指数测量，肾脏疾病快速进展的风险增加。常染色体显性遗传性多囊肾病导致肾囊肿的生长和增殖，导致大多数成年人肾功能下降。脂肪组织的积累可能通过影响各种细胞信号传导途径进一步加剧与ADPKD相关的代谢缺陷。通过减少脂肪组织和系统性炎症，诱导体重减轻的生活方式干预可能有助于延缓疾病进展。需要进一步的研究来确定脂肪组织对疾病进展的机制影响。
Obesity remains a growing public health concern in industrialized countries around the world. The prevalence of obesity has also continued to rise in those with chronic kidney disease. Epidemiological data suggests those with overweight and obesity, measured by body mass index, have an increased risk for rapid kidney disease progression. Autosomal dominant polycystic kidney disease causes growth and proliferation of kidney cysts resulting in a reduction in kidney function in the majority of adults. An accumulation of adipose tissue may further exacerbate the metabolic defects that have been associated with ADPKD by affecting various cell signaling pathways. Lifestyle interventions inducing weight loss might help delay disease progression by reducing adipose tissue and systematic inflammation. Further research is needed to determine the mechanistic influence of adipose tissue on disease progression.