Neuronal encoding of subjective value in dorsal and ventral anterior cingulate cortex.
Neuronal encoding of subjective value in dorsal and ventral anterior cingulate cortex.
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DOI：
10.1523/jneurosci.3864-11.2012
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发表时间：
2012-03-14
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影响因子：
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通讯作者：
Padoa-Schioppa C
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文献类型：
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作者：
Cai X;Padoa-Schioppa C
我们研究了灵长类动物前扣带皮层中单个细胞在经济选择任务中的活动。在实验中，猴子在不同数量的果汁中做出选择，主观价值是从动物的选择中推断出来的。我们分析了神经元放电率与大量行为相关变量的关系。我们报告三个主要结果。首先，有强大的差异背侧银行（ACCd）和腹侧银行（ACCV）扣带沟。具体而言，在ACCd，但不是在ACCV的神经元调制的运动方向。此外，ACCd中的神经元在运动开始前最活跃，而ACCV中的神经元在果汁递送后最活跃。第二，这两个区域的神经元对动物选择的果汁的身份和主观价值进行编码。相比之下，这两个地区都没有对个人出价的价值进行编码。第三，ACCd和ACCV的值编码神经元的人口进行范围适应。关于经济选择，有趣的是将这些区域与先前研究的眶额皮质（OFC）进行比较。虽然OFC中的神经元编码决策前和决策后变量，但ACCd和ACCV中的神经元仅编码决策后变量。此外，ACCd和ACCv中选择值的编码落后于OFC。这些观察结果表明，经济决策（价值比较）发生在ACCd和ACCV的上游。ACCd的选择结果和运动信号的共存表明，这一领域构成了一个逃跑，通过选择系统通知运动系统。
We examined the activity of individual cells in the primate anterior cingulate cortex during an economic choice task. In the experiments, monkeys chose between different juices offered in variables amounts and subjective values were inferred from the animals’ choices. We analyzed neuronal firing rates in relation to a large number of behaviorally relevant variables. We report three main results. First, there were robust differences between the dorsal bank (ACCd) and the ventral bank (ACCv) of the cingulate sulcus. Specifically, neurons in ACCd but not in ACCv were modulated by the movement direction. Furthermore, neurons in ACCd were most active prior to movement initiation whereas neurons in ACCv were most active after juice delivery. Second, neurons in both areas encoded the identity and the subjective value of the juice chosen by the animal. In contrast, neither region encoded the value of individual offers. Third, the population of value-encoding neurons in both ACCd and ACCv underwent range adaptation. With respect to economic choice, it is interesting to compare these areas with the orbitofrontal cortex (OFC), previously examined. While neurons in OFC encoded both pre-decision and post-decision variables, neurons in ACCd and ACCv only encoded post-decision variables. Moreover, the encoding of chosen value in ACCd and ACCv trailed that found in OFC. These observations indicate that economic decisions (value comparisons) take place upstream of ACCd and ACCv. The coexistence of choice outcome and movement signals in ACCd suggests that this area constitutes a getaway through which the choice system informs motor systems.