MEIS and PBX homeobox proteins in ovarian cancer
MEIS and PBX homeobox proteins in ovarian cancer
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DOI：
10.1016/j.ejca.2007.08.025
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发表时间：
2007-11-01
影响因子：
8.4
通讯作者：
de Vries, E. G. E.
中科院分区：
文献类型：
--
作者：
Crijns, A. P. G.;de Graeff, P.;de Vries, E. G. E.
三种氨基酸环延伸（TALE）同源盒蛋白MEIS和PBX是HOX类同源盒蛋白的辅因子，其控制胚胎发生和稳态期间的生长和分化。我们发现MEIS和PBX的表达与卵巢癌细胞系顺铂耐药有关。因此，MEIS1、MEIS2和PBX表达在卵巢癌（N = 232）和卵巢表面上皮（N = 15）的组织微阵列中进行化学研究。结果与临床病理特征和生存有关。MEIS 1、MEIS 2和PBX在所有癌细胞的胞核和胞浆中均有表达。MEIS 1和2只在表面上皮细胞核中染色。在单因素分析中，核MEIS2与分期、分级和总生存率呈负相关。此外，使用公共阵列数据集研究了卵巢表面上皮和其他正常组织以及卵巢癌与其他肿瘤类型中的MEIS和PBX RNA表达。在卵巢癌中，MEIS1与其他癌症类型相比高度表达。总之，MEIS和PBX在卵巢癌中广泛表达，并可能在卵巢癌发生中发挥作用。(c)2007爱思唯尔有限公司版权所有
Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved