Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
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DOI：
10.1126/science.1142490
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发表时间：
2007-09-21
期刊：
影响因子：
56.9
通讯作者：
Werren, John H.
中科院分区：
文献类型：
--
作者：
Hotopp, Julie C. Dunning;Clark, Michael E.;Werren, John H.
尽管横向基因转移在细菌中很常见，但在远亲生物之间的基因转移被认为很少发生在细菌和多细胞真核生物之间。然而，内共生体，如Wolbachia pipientis，在一些真核生物生殖细胞内的存在可能有助于细菌基因转移到真核宿主基因组。因此，我们研究了宿主基因组的证据，从沃尔巴克氏体细菌的基因转移事件，他们的主机。我们发现并证实了四种昆虫和四种线虫的基因组中的转移，范围从几乎整个沃尔巴克氏体基因组（>1兆碱基）到短的（
Although common among bacteria, lateral gene transfer-the movement of genes between distantly related organisms-is thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes. We therefore examined host genomes for evidence of gene transfer events from Wolbachia bacteria to their hosts. We found and confirmed transfers into the genomes of four insect and four nematode species that range from nearly the entire Wolbachia genome (>1 megabase) to short (