The Study of Interference with Ruyanneixiao Cream on Hemorheology and Mammary Microcirculation of Mammary Precancer Rats
The Study of Interference with Ruyanneixiao Cream on Hemorheology and Mammary Microcirculation of Mammary Precancer Rats
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DOI：
10.4028/www.scientific.net/amr.554-556.1789
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发表时间：
2012-07
期刊：
影响因子：
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通讯作者：
Guijuan Zhang;Dehui Li;Rui Liao;Bizhu Tan;Y. Liu;Yi Ma;S. Zhang;Min Ma;X. Zeng;Yi Lin;Zhuolong Peng
中科院分区：
文献类型：
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作者：
Guijuan Zhang;Dehui Li;Rui Liao;Bizhu Tan;Y. Liu;Yi Ma;S. Zhang;Min Ma;X. Zeng;Yi Lin;Zhuolong Peng
Objective: to probe the interference of Ruyanneixiao cream for hemorheology and mammary microcirculation of mammary precancer rats. Methods: 48 virginal female SD rats were randomly allocated into 6 groups, A: Blank control group (8); B: Mammary precancer model group (8); C: Tamoxifen (TAM) group (8); D: High dose group of Ruyanneixiao cream (8); E: Middle dose group of Ruyanneixiao cream (8); F: Low dose group of Ruyanneixiao cream (8). The changes of hemorheology and mammary microcirculation were recorded when the rats were executed after 60d. Result: compared with the Blank control group, the whole blood viscosity and plasma viscosity of mammary precancer model group was higher (P<0.05) and the perfusion of mammary microcirculation was lower (P<0.01). Compared with mammary precancer model group, the hemorheological parameters and perfusion of mammary microcirculation of each dose group of Ruyanneixiao cream were improved (P<0.05). Conclusion: Ruyanneixiao cream can improve the status of hemorheology, increase the perfusion of mammary microcirculation. And it may be one of mechanism to treat and prevent mammary precancer disease.
