A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans.
A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans.
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DOI：
10.1016/j.neuron.2018.01.014
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发表时间：
2018-02-07
期刊：
影响因子：
16.2
通讯作者：
Jin Y
中科院分区：
文献类型：
--
作者：
Kim KW;Tang NH;Andrusiak MG;Wu Z;Chisholm AD;Jin Y
The PIWI-interacting RNA (piRNA) pathway has long been thought to function solely in the germline, but evidence for its functions in somatic cells is emerging. Here we report an unexpected role for the piRNA pathway in Caenorhabditis elegans sensory axon regeneration after injury. Loss of function in a subset of components of the piRNA pathway results in enhanced axon regrowth. Two essential piRNA factors, PRDE-1 and PRG-1/PIWI, inhibit axon regeneration in a gonad-independent and cell-autonomous manner. By smFISH analysis we find that prde-1 transcripts are present in neurons, as well as germ cells. The piRNA pathway inhibits axon regrowth independent of nuclear transcriptional silencing but dependent on the slicer domain of PRG-1/PIWI, suggesting post-transcriptional gene silencing is involved. Our results reveal the neuronal piRNA pathway as a novel intrinsic repressor of axon regeneration. Kim et al. discovered that specific factors in the PIWI-interacting small RNA (piRNA) pathway inhibit axon regeneration in C. elegans. Transcripts of the piRNA factor prde-1 are present in neurons and piRNA factors function cell-autonomously to limit axon regeneration.
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影响因子：
64.5
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Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
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作者：
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影响因子：
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4.6
作者：
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通讯作者：
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DOI：
10.1126/science.1157647
发表时间：
2008-07-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Guang S;Bochner AF;Pavelec DM;Burkhart KB;Harding S;Lachowiec J;Kennedy S
通讯作者：
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