Uterine adenocarcinoma in mice treated neonatally with genistein.
Uterine adenocarcinoma in mice treated neonatally with genistein.
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发表时间：
2001-06
期刊：
影响因子：
11.2
通讯作者：
R. Newbold;E. P. Banks;Bill C. Bullock;W. Jefferson
中科院分区：
文献类型：
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作者：
R. Newbold;E. P. Banks;Bill C. Bullock;W. Jefferson
发育中的胎儿对雌激素化学物质的干扰特别敏感。产前暴露于己烯雌酚（DES）的致癌作用是一个典型的例子。由于植物雌激素在婴儿和儿童营养和药物应用中的使用正在增加，我们研究了染料木黄酮（大豆中天然存在的植物雌激素）的致癌潜力，在先前报道的实验动物模型中，新生儿DES暴露后子宫腺癌的发病率很高。在第1-5天用等同雌激素剂量的DES（0.001 mg/kg/天）或染料木黄酮（50 mg/kg/天）处理远交雌性CD-1小鼠。18个月时，染料木素组子宫腺癌的发生率为35%，DES组为31%。这些数据表明，染料木黄酮是致癌的，如果暴露发生在分化的关键时期。因此，应密切审查在没有医疗需要的情况下使用大豆婴儿配方奶粉以及销售旨在吸引儿童的豆制品的情况。
The developing fetus is uniquely sensitive to perturbation with estrogenic chemicals. The carcinogenic effect of prenatal exposure to diethylstilbestrol (DES) is the classic example. Because phytoestrogen use in nutritional and pharmaceutical applications for infants and children is increasing, we investigated the carcinogenic potential of genistein, a naturally occurring plant estrogen in soy, in an experimental animal model previously reported to result in a high incidence of uterine adenocarcinoma after neonatal DES exposure. Outbred female CD-1 mice were treated on days 1-5 with equivalent estrogenic doses of DES (0.001 mg/kg/day) or genistein (50 mg/kg/day). At 18 months, the incidence of uterine adenocarcinoma was 35% for genistein and 31% for DES. These data suggest that genistein is carcinogenic if exposure occurs during critical periods of differentiation. Thus, the use of soy-based infant formulas in the absence of medical necessity and the marketing of soy products designed to appeal to children should be closely examined.