AGING AND TOTAL CHOLESTEROL LEVELS - COHORT, PERIOD, AND SURVIVORSHIP EFFECTS
AGING AND TOTAL CHOLESTEROL LEVELS - COHORT, PERIOD, AND SURVIVORSHIP EFFECTS
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DOI：
10.1093/oxfordjournals.aje.a116417
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发表时间：
1992-07-01
影响因子：
5
通讯作者：
HALE, WE
中科院分区：
文献类型：
--
作者：
NEWSCHAFFER, CJ;BUSH, TL;HALE, WE
这项分析描述了5,010名老年健康筛查项目参与者的年龄与血清总胆固醇水平的关系。每年对监测长达12年的参与者进行胆固醇水平测量。年龄与胆固醇水平的关联通过三种方法来描述：横断面分析，描述性纵向分析，以及使用统计建模的纵向分析。比较结果以检查队列、时期和存活率对年龄和胆固醇之间关系的影响。在横断面分析中，胆固醇水平在65至75岁之间相当稳定，但在75至95岁之间下降了21%。描述性纵向分析表明，队列和时期的影响，横断面的结果。在调整队列和时期效应的纵向分析中，65至75岁年龄组的结果与横断面分析的结果相似，但从75至95岁，胆固醇仅下降了9%，是横断面分析估计的下降幅度的一半。当纵向数据仅限于那些有完整随访的患者时，75至95岁年龄段的预测下降仅为6%。尽管这种年龄趋势的平坦化是有暗示性的，但没有确凿的证据表明它反映了基线胆固醇和失访之间的关联。
This analysis describes the association of age with the serum total cholesterol level in 5,010 participants in a geriatric health screening program. Cholesterol levels were measured annually in participants monitored for up to 12 years. The association of age with cholesterol level is described via three approaches: cross-sectional analysis, descriptive longitudinal analysis, and longitudinal analysis using statistical modeling. The results were compared to examine the influence of cohort, period, and survivorship effects on the association between age and cholesterol. In cross-sectional analysis, the cholesterol level was fairly constant for the ages of 65 to 75 years, but decreased by 21% over the age range from 75 to 95 years. Descriptive longitudinal analysis suggested that both cohort and period effects were influencing the cross-sectional findings. In longitudinal analysis adjusting for both cohort and period effects, the findings were similar to those from cross-sectional analysis for the ages of 65 to 75 years, but from the ages of 75 to 95 years, cholesterol decreased by only 9%-half as great a decline as that estimated from cross-sectional analysis. When longitudinal data were limited to those with complete follow-up, the predicted decline for the age range from 75 to 95 years was only 6%. Although this flattening of the age trend was suggestive, there was no conclusive evidence that it reflected an association between baseline cholesterol and loss to follow-up.