THE STRUCTURE OF AN OLIGO(DA).OLIGO(DT) TRACT AND ITS BIOLOGICAL IMPLICATIONS
THE STRUCTURE OF AN OLIGO(DA).OLIGO(DT) TRACT AND ITS BIOLOGICAL IMPLICATIONS
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DOI：
10.1038/330221a0
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发表时间：
1987-11-19
期刊：
影响因子：
64.8
通讯作者：
KLUG, A
中科院分区：
文献类型：
--
作者：
NELSON, HCM;FINCH, JT;KLUG, A
Poly（dA）·poly（dT）具有不寻常的性质，因为它不能与核小体结合，并且它的短时间，分阶段运行会导致DNA弯曲。一个B型DNA十二聚体的晶体结构显示，该区域具有特殊的结构特征，包括分叉氢键系统，这解释了这种简单均聚物的一些性质。
Poly (dA)·poly (dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A·T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.