Network Analysis of Resting State EEG in the Developing Young Brain: Structure Comes With Maturation
Network Analysis of Resting State EEG in the Developing Young Brain: Structure Comes With Maturation
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DOI：
10.1002/hbm.21030
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发表时间：
2011-03-01
影响因子：
4.8
通讯作者：
Stam, Cornelis J.
中科院分区：
文献类型：
--
作者：
Boersma, Maria;Smit, Dirk J. A.;Stam, Cornelis J.
在童年时期，大脑结构和功能发生了重大变化。最近，图论被引入到大脑的连接模型中。小世界网络，如大脑，结合了有序和随机网络的联合收割机最佳特性，即，高集群和短路径长度。我们使用图论概念来研究幼儿正常发育过程中功能性大脑网络的变化。记录了227名5岁和7岁儿童的静息状态闭眼脑电图（EEG）（14个通道）。同步似然（SL）计算在三个不同的频带和每对电极之间，以获得SL加权图。通过计算平均归一化聚类指数、平均路径长度和权值离散度来表征网络组织结构。重复测量方差分析测试时间和性别的影响。对于所有频段，平均SL从5岁下降到7岁。α波段的聚类系数增大。路径长度在所有频带中增加。β带的平均标准化体重离散度降低。女孩表现出更高的同步所有频段和更高的平均聚类在α和β波段。功能连接性（SL）的整体下降可能反映了未使用突触的修剪和强连接的保留，从而产生更具成本效益的网络。因此，我们发现平均聚类和路径长度增加，权重分散度降低，表明正常大脑成熟的特征是从随机到更有组织的小世界功能网络的转变。这一发展过程在发展早期受到性别差异的影响。《脑地图》32：413-425，2011年。(C)2010 Wiley-Liss，Inc.
During childhood, brain structure and function changes substantially. Recently, graph theory has been introduced to model connectivity in the brain. Small-world networks, such as the brain, combine optimal properties of both ordered and random networks, i.e., high clustering and short path lengths. We used graph theoretical concepts to examine changes in functional brain networks during normal development in young children. Resting-state eyes-closed electroencephalography (EEG) was recorded (14 channels) from 227 children twice at 5 and 7 years of age. Synchronization likelihood (SL) was calculated in three different frequency bands and between each pair of electrodes to obtain SL-weighted graphs. Mean normalized clustering index, average path length and weight dispersion were calculated to characterize network organization. Repeated measures analysis of variance tested for time and gender effects. For all frequency bands mean SL decreased from 5 to 7 years. Clustering coefficient increased in the alpha band. Path length increased in all frequency bands. Mean normalized weight dispersion decreased in beta band. Girls showed higher synchronization for all frequency bands and a higher mean clustering in alpha and beta bands. The overall decrease in functional connectivity (SL) might reflect pruning of unused synapses and preservation of strong connections resulting in more cost-effective networks. Accordingly, we found increases in average clustering and path length and decreased weight dispersion indicating that normal brain maturation is characterized by a shift from random to more organized small-world functional networks. This developmental process is influenced by gender differences early in development. Hum Brain Mapp 32:413-425, 2011. (C) 2010 Wiley-Liss, Inc.