Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees
Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees
复制标题
DOI：
10.1016/j.drugalcdep.2014.11.034
复制
发表时间：
2015-02-01
影响因子：
4.2
通讯作者：
Miyashita, Kazuhisa
中科院分区：
文献类型：
--
作者：
Yoshimasu, Kouichi;Mure, Kanae;Miyashita, Kazuhisa
背景资料：虽然酒精相关性障碍（ARD）已被证明伴有抑郁症和焦虑症的共病，并且酒精代谢酶基因ADH 1B和ALDH 2多态性与ARD的风险增加有关，但尚未进行研究来评估这些基因多态性与焦虑或抑郁症之间的关联。共有1944名日本工人接受了采访，他们的抑郁症和焦虑症，包括自杀倾向，一个简短的精神结构化访谈（MINI）。我们研究了ADH 1B rs 1229984和ALDH 2 rs671多态性组合与精神障碍风险的关系。Logistic回归分析用于评估这些多态性与焦虑/抑郁障碍之间的关联，调整性别，年龄和工作级别。结果：ALDH 2 *1/*1和ADHIB *1/*1基因型的受试者发生抑郁症、焦虑症和ARD的危险性增加。这种趋势在不饮酒者中更为明显（OR 9.20，95%CI 1.66-50.89）。单独使用ALDH 2或ADH 1B没有观察到精神障碍风险的不良影响。同样，结合工作等级和遗传酒精敏感性进行的分析表明，没有物质与这样的risk.Conclusions：遗传酒精敏感性，特别是与ALDH 2 * 11 '1和ADH 1B *10的基因型组合，是显着相关的抑郁症和焦虑症以及ARD的风险增加。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Although alcohol-related disorders (ARD) have been shown to be accompanied by comorbid depressive and anxiety disorders, and alcohol metabolic enzyme genes, ADH1B and ALDH2 polymorphisms, have been associated with an increased risk of ARD, no studies have been conducted to evaluate the associations between these genetic polymorphisms and anxiety or depression.Method: A total of 1944 Japanese workers were interviewed regarding their depressive and anxiety disorders, including suicidality, by a brief psychiatric structured interview (MINI). We investigated the relationship of ADH1B rs1229984 and ALDH2 rs671 polymorphism combinations with mental disorder risks. Logistic regression analysis was used to evaluate the associations between those polymorphisms and anxiety/depressive disorders, adjusting for sex, age, and job rank. The degree of alcohol sensitivity was classified into five groups according to the combination of two enzyme genotypes (Group I-V, in order from the lowest alcohol sensitivity).Results: Those with ALDH2 *1/*1 and ADHIB *1/*1 were likely to be at an increased risk of depressive and anxiety disorders as well as ARD. This tendency was more apparent among non-drinkers (OR 9.20, 95% CI 1.66-50.89). No adverse effects of ALDH2 or ADH1B alone were observed with mental disorder risks. Likewise, analyses conducted combining job rank and genetic alcohol sensitivity showed no material associations with such risks.Conclusions: Genetic alcohol sensitivity, especially that with the genotype combination of ALDH2 *11'1 and ADH1B *10, was significantly associated with an increased risk of depressive and anxiety disorders as well as ARD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.