A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways
A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways
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DOI：
10.1155/2019/1719829
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发表时间：
2019-04
影响因子：
3.1
通讯作者：
Xiyue Ye;Yan Qiu;Yuqing Gao;Dong Wan;Huifeng Zhu
中科院分区：
文献类型：
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作者：
Xiyue Ye;Yan Qiu;Yuqing Gao;Dong Wan;Huifeng Zhu
早期神经系统发育和轴突再生的一个基本特征是引导轴突投射到它们的目标，以组装控制行为的神经回路。在神经向其目标生长的导航过程中，位于轴突尖端的生长锥感知周围的环境，包括各种吸引或排斥的分子线索，然后做出方向决定以调整其导航旅程。生长锥的旋转能力很大程度上取决于其高度动态的骨架，其中肌动蛋白丝和微管在其运动中起着非常重要的作用。本文就生长锥运动的可能机制、相关的分子线索和轴突导向的信号通路等方面的研究进展进行综述，并对今后的研究方向进行探讨。
A fundamental feature of both early nervous system development and axon regeneration is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. In the navigation process where the nerves grow toward their targets, the growth cones, which locate at the tips of axons, sense the environment surrounding them, including varies of attractive or repulsive molecular cues, then make directional decisions to adjust their navigation journey. The turning ability of a growth cone largely depends on its highly dynamic skeleton, where actin filaments and microtubules play a very important role in its motility. In this review, we summarize some possible mechanisms underlying growth cone motility, relevant molecular cues, and signaling pathways in axon guidance of previous studies and discuss some questions regarding directions for further studies.