SERUM-PROTEIN BINDING AND THE ROLE OF INCREASED ALPHA-1-ACID GLYCOPROTEIN IN MODERATELY OBESE MALE-SUBJECTS
SERUM-PROTEIN BINDING AND THE ROLE OF INCREASED ALPHA-1-ACID GLYCOPROTEIN IN MODERATELY OBESE MALE-SUBJECTS
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DOI：
10.1111/j.1365-2125.1984.tb02567.x
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
MCNAMARA, PJ
中科院分区：
文献类型：
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作者：
BENEDEK, IH;BLOUIN, RA;MCNAMARA, PJ
测定了正常体重和肥胖志愿者的血清蛋白和脂质浓度以及普萘洛尔、地西泮和苯妥英钠的血清蛋白结合率。肥胖受试者中α 1-酸性糖蛋白（AAG）的浓度是瘦对照的两倍。肥胖组高密度脂蛋白（HDL）浓度降低。普萘洛尔的血清结合在肥胖受试者中增加，并且与血清AAG浓度相关。地西泮结合轻微下降，肥胖的结果，较低的血清白蛋白浓度和游离脂肪酸升高。在所有志愿者中，苯妥英的结合率相当。这些发现指出了与肥胖相关的一些复杂的病理生理学变化，这可能反过来影响药物处置，从而影响肥胖患者的药物治疗。
Serum protein and lipid concentrations as well as the serum protein binding of propranolol, diazepam and phenytoin were measured in normal weight and obese volunteers. Concentrations of .alpha.1-acid glycoprotein (AAG) in the obese subjects were double that of the lean controls. Concentrations of high density lipoproteins (HDL) were decreased in the obese group. The serum binding of propranolol was increased in the obese subjects and correlated with serum AAG concentrations. Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentration and elevated free fatty acids. The binding of phenytoin was comparable in all of the volunteers. These findings point out some of the complex pathophysiologic changes associated with obesity, which may in turn influence drug disposition and hence drug therapy in the obese patient.