NEURONAL COUNTS FROM 4 CORTICAL REGIONS OF ALCOHOLIC BRAINS
NEURONAL COUNTS FROM 4 CORTICAL REGIONS OF ALCOHOLIC BRAINS
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DOI：
10.1007/bf00294379
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发表时间：
1989-01-01
影响因子：
12.7
通讯作者：
HARPER, CG
中科院分区：
文献类型：
--
作者：
KRIL, JJ;HARPER, CG
最近有证据表明，酗酒者大脑额叶上皮层的神经元丢失。除此之外，额叶和运动皮层的平均神经元面积也有所减少。这表明了酗酒者大脑中神经元损伤的区域特异性。对上述研究中使用的相同病例的其他皮质区域进行了进一步的定量分析。检查了额扣带和颞叶皮层，发现与对照组相比，神经元数量没有明显变化。然而，额扣带皮层神经元体的平均大小显著减少（P < 0.05）。这些数据支持了酒精中毒大脑皮层损伤严重程度的区域差异假设，在大多数被检查的区域，神经元萎缩，但神经元损失仅在额上回。
Neuronal loss from the frontal superior cortex of the brains of alcoholics has recently been documented. In addition to this, a reduction in the mean neuronal area was also seen in the frontal and motor cortices. This suggested a regional specificity of neuronal damage in the brains of alcoholics. Further quantitation of other cortical regions of the same cases as used in the above study has been performed. The frontal cingulate and temporal cortices were examined and there was found to be no significant alteration in the number of neurons when compared to a control population. There was, however, a significant reduction in the mean size of the neuronal soma in the frontal cingulate cortex (P < 0.05). These data support the hypothesis of regional variations in the severity of cerebral cortical damage in alcoholism with shrinkage of neurons in most regions examined but neuronal loss only in the superior frontal gyrus.