Tailor-made antibody therapeutics
Tailor-made antibody therapeutics
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DOI：
10.1016/j.ymeth.2005.01.002
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发表时间：
2005-05-01
期刊：
影响因子：
4.8
通讯作者：
Wu, H
中科院分区：
文献类型：
--
作者：
Chowdhury, PS;Wu, H
治疗性抗体是制药行业发展最快的领域之一。目前市场上有18种单克隆抗体已被FDA批准，超过150种单克隆抗体处于临床开发阶段。在创新和技术发展的推动下，科学家们已经超越了传统的抗体分子。为了应对不同生物环境带来的挑战，抗体已经以各种方式被设计出来。在这篇综述中描述的是一个不同的方式，抗体已被量身定制，使其有效的药物分子的简要说明。(c) 2005爱思唯尔公司版权所有。
Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 18 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, scientists have gone beyond the traditional antibody molecules. Antibodies have been engineered in a variety of ways to meet the challenges posed by different biological settings. Described in this review is an abridged account of the different ways antibodies have been tailored to make them efficient drug molecules. (c) 2005 Elsevier Inc. All rights reserved.