Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene
Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene
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DOI：
10.1046/j.1469-7580.1997.19020201.x
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发表时间：
1997-02-01
影响因子：
2.4
通讯作者：
Ronning, O
中科院分区：
文献类型：
--
作者：
Rintala, M;Metsaranta, M;Ronning, O
Skull morphology and histology in the heterozygous offspring of a transgenic founder mouse Del1, harbouring 6 copies of deletion mutation in Col2a1 gene, were compared with those in normal siblings. On visual observation and roentgenocephalometric examination the heads of heterozygous Del1 mice were smaller than normal. Histologically the sizes of cartilaginous structures of the cranial base were reduced. Severe defects were seen in the temporomandibular joint as progressive osteoarthritic lesions. These observations elucidate the relationship between the genotype and phenotype and demonstrate that heterozygous Del1 mice are a useful model for studies on a genetic disturbance where 'clinical' manifestations are not evident until adult age.
