The temporal-distance effect in subjects with dementia of the Alzheimer type.
The temporal-distance effect in subjects with dementia of the Alzheimer type.
复制标题
阿尔茨海默型痴呆症患者的时间距离效应。
DOI：
10.1097/00002093-199509020-00006
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kesner,RP
中科院分区：
文献类型：
--
作者：
Madsen,J;Kesner,RP
在大学生、老年对照组和轻度和中度阿尔茨海默型痴呆（DAT）受试者中评估了空间位置的时间-距离处理的功效。老年人控制组的表现略低于大学生，但老年人控制组和大学生都表现出时间-距离效应。轻度DAT受试者仅在最大的时间距离上准确地执行任务。中度DAT受试者在所有距离的机会水平。由于在人类和海马或前额叶皮质损伤较小的动物中，时间距离功能也发生了类似的变化，因此在阿尔茨海默病的早期阶段，可能存在重要的海马或前额叶皮质受累或两者兼而有之。
The efficacy of temporal-distance processing for spatial locations was evaluated in college students, elderly controls, and subjects with mild and moderate dementia of the Alzheimer type (DAT). The elderly controls showed a slightly lower level of performance than college students, but both elderly controls and college students displayed a temporal-distance effect. The mild DAT subjects performed the task accurately only at the greatest temporal distances. The moderate DAT subjects performed at chance levels for all distances. Because similar changes in the temporal-distance function have been described for humans and animals with small hippocampal or prefrontal cortex damage, there might be important hippocampal or prefrontal cortex involvement or both in early stages of Alzheimer disease.