Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon
Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon
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DOI：
10.1186/1471-2334-12-216
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发表时间：
2012-09-13
影响因子：
3.7
通讯作者：
Kombila, Maryvonne
中科院分区：
文献类型：
--
作者：
Bouyou-Akotet, Marielle Karine;Mawili-Mboumba, Denise Patricia;Kombila, Maryvonne
背景：尽管在实施新的控制战略后，非洲观察到恶性疟原虫感染大幅下降，但疟疾仍然被认为是非洲住院儿童发热性疾病的主要原因。本研究旨在评估发热性疾病的管理，并确定在加蓬利伯维尔实施新的疟疾控制战略后，因疟疾初步诊断而住院的发热性疾病儿童确诊为复杂疟疾的比例。方法：2008年在利伯维尔医院中心进行的一项前瞻性和观察性研究中，记录并分析了年龄小于18岁的发热或有发热史、初步诊断为临床疟疾的住院儿童的人口统计学、临床和生物学数据，这些儿童受益于血液学测量和显微镜下的疟疾诊断。结果：共有418例发热儿童作为疟疾病例入院。其中大多数（79.4%）的年龄在五岁以下。经医学检查，168人被诊断和治疗为临床疟疾，其中只有56.7% （n = 95）血液涂片呈恶性疟原虫阳性。年龄大于5岁，面色苍白，布兰太尔昏迷评分
Background: Although a substantial decline of Plasmodium falciparum infection is observed in Africa following implementation of new control strategies, malaria is still considered as the major cause of febrile illness in hospitalized African children. The present study was designed to assess the management of febrile illness and to determine the proportion of children with febrile illness hospitalized for primary diagnosis of malaria who had confirmed complicated malaria after implementation of new malaria control strategies in Libreville, Gabon.Methods: Demographic, clinical and biological data from hospitalized children with fever or a history of fever, with a primary diagnosis of clinical malaria, aged less than 18 years old, who benefited from hematological measurements and microscopic malaria diagnosis, were recorded and analyzed during a prospective and observational study conducted in 2008 in the Centre Hospitalier de Libreville.Results: A total of 418 febrile children were admitted at hospital as malaria cases. Majority of them (79.4%) were aged below five years. After medical examination, 168 were diagnosed and treated as clinical malaria and, among them, only 56.7% (n = 95) had Plasmodium falciparum positive blood smears. Age above five years, pallor, Blantyre Coma Score