Synthesis of Optically Active α-Alkylidene-β-hydroxy-γ-methylenebutyrolactones. Isoobtusilactones and Isomahubalactones (Isomahubanolide and Isomahubenolide)
Synthesis of Optically Active α-Alkylidene-β-hydroxy-γ-methylenebutyrolactones. Isoobtusilactones and Isomahubalactones (Isomahubanolide and Isomahubenolide)
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光学活性 α-亚烷基-β-羟基-γ-亚甲基丁内酯和异木马内酯（Isomahubanolide 和 Isomahubenolide）的合成。
DOI：
10.1246/cl.1992.1647
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发表时间：
1992
影响因子：
1.6
通讯作者：
N. Kunieda
中科院分区：
文献类型：
--
作者：
J. Nokami;Hirotoshi Ohtsuki;Y. Sakamoto;M. Mitsuoka;N. Kunieda
以α，β-不饱和羧酸根α-阴离子等价物与二异丙基溴化镁酰胺为原料，通过立体选择性的Aldol反应，以炔丙基醛为关键步骤，合成了标题化合物。
The title compounds were prepared via stereoselective aldol reaction of α,β-unsaturated carboxylate α-anion equivalent, derived from optically active α-(arylsulfinyl)carboxylate and bromomagnesium diisopropylamide, with propargyl aldehyde as a key step.