Protein kinase C regulates leukotriene B4 receptors in human neutrophils.
Protein kinase C regulates leukotriene B4 receptors in human neutrophils.
复制标题
蛋白激酶 C 调节人中性粒细胞中的白三烯 B4 受体。
DOI：
10.1016/0014-5793(86)80996-6
复制
发表时间：
1986
期刊：
影响因子：
3.5
通讯作者：
Jacobson,DP
中科院分区：
文献类型：
--
作者：
O'Flaherty,JT;Redman,JF;Jacobson,DP
Three protein kinase C (PKC) activators, viz. phorbol myristate acetate, mezerein, andrac‐1‐O‐myristoyl‐2‐acetylglycerol, inhibited human neutrophil binding of [3H] leukotriene B4(LTB4) by reducing the number of high‐affinity receptors available to the arachidonic acid metabolite. The inhibitory effect occurred in whole cells and cytoplasts but not in isolated membranes; it appeared to involve the activation of PKC rather than direct competition for binding sites. PKC may govern cellular responsiveness by regulating the receptor‐linked bioactions of endogenous mediators like LTB4.
