THE ROLE OF GUT-ASSOCIATED LYMPHOID-TISSUES IN THE GENERATION OF IMMUNOGLOBULIN-BEARING LYMPHOCYTES IN SHEEP
THE ROLE OF GUT-ASSOCIATED LYMPHOID-TISSUES IN THE GENERATION OF IMMUNOGLOBULIN-BEARING LYMPHOCYTES IN SHEEP
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DOI：
10.1038/icb.1986.22
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发表时间：
1986-06-01
期刊：
影响因子：
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通讯作者：
TREVELLA, W
中科院分区：
文献类型：
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作者：
GERBER, HA;MORRIS, B;TREVELLA, W
本实验旨在研究派尔集合淋巴结和肠系膜淋巴结对绵羊循环免疫球蛋白携带淋巴细胞群体的相对贡献。从不同发育阶段的羔羊中取出回肠（占总派伊尔淋巴结的90%以上）、肠系膜淋巴结或两者，并检查不同来源淋巴液和血液中细胞群的组成。在出生前或出生后几天内切除回肠的羔羊缺乏携带膜免疫球蛋白的小淋巴细胞。这种赤字至少在动物生命的第一年仍然存在。肠系膜淋巴结的去除或回肠的去除对细胞的总输出或对从肠道排出的淋巴液中的IgA产生细胞的群体都没有任何统计学显著影响。
Experiments were designed to examine the relative contributions of Peyer''s patches and mesenteric lymph nodes to the population of circulating immunoglobulin-bearing lymphocytes in sheep. The ileum, with more than 90% of the total Peyer''s patches, the mesenteric lymph nodes, or both, were removed from lambs at different stages of development and the composition of the cell populations in lymph from different sources and in the blood was examined. Lambs which had had the ileum removed before or within a few days of birth were deficient in small lymphocytes bearing membrane immunoglobulin. This deficit remained for at least the first year of the animals'' lives. Neither the removal of mesenteric lymph nodes nor removal of the ileum had any statistically significant effect on the total output of cells or on the population of IgA-producing cells in lymph draining from the gut.