CORTICAL CONTROL OF REFLEXIVE VISUALLY-GUIDED SACCADES
CORTICAL CONTROL OF REFLEXIVE VISUALLY-GUIDED SACCADES
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DOI：
10.1093/brain/114.3.1473
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发表时间：
1991-06-01
期刊：
影响因子：
14.5
通讯作者：
AGID, Y
中科院分区：
文献类型：
--
作者：
PIERROTDESEILLIGNY, C;RIVAUD, S;AGID, Y
反射性视觉引导扫视触发可以由大脑皮层促进或抑制。 为了研究这种控制，对45名患有局限性单侧脑梗死的患者进行了眼电描记，记录了朝向突然出现的视觉目标（眼跳任务）或远离视觉目标（反眼跳任务）的眼跳。 病变累及（1）后顶叶皮层（PPC）角回的上级部分（Brodmann的39区），（2）背外侧前额叶皮层（PFC）（Brodmann的46区），（3）额叶眼野（FEF），或（4）辅助运动区（SMA）。 由于这4种类型的病变位于右侧或左侧大脑半球，因此将患者分为8组。 扫视潜伏期，在扫视任务，和错误的百分比（错误的扫视对视觉目标），在反扫视任务，进行了比较，在每组患者的值与20个对照组。 在扫视任务中，右侧PPC组的扫视潜伏期显著增加。 在左侧PPC组中，潜伏期的增加不太明显，仅对病变对侧的扫视有显著意义。 在不同的额叶组，潜伏期不变或仅略有增加。 这些结果证实了促进反射性视觉引导扫视触发的主要区域位于PPC中，在角回的上级部分中或附近。 右顶叶和左顶叶病变之间的差异可能是由于右半球在控制这些眼跳方面占主导地位。 在反跳跃任务中，与对照组相比，PFC组的双侧错误百分比显著增加，FEF组和SMA组也是如此。 这些结果表明，PFC是大脑半球抑制反射性视觉引导扫视的主要区域。
Reflexive visually-guide saccade triggering may be facilitated or inhibited by the cerebral cortex. To study this control, saccades made towards suddenly appearing visual targets (saccade task) or away from them (antisaccade task) were recorded electro-oculographically in 45 patients with limited unilateral cerebral infraction. Lesions affected (1) the superior part of the angular gyrus (area 39 of Brodmann) in the posterior parietal cortex (PPC), (2) the dorsolateral prefrontal cortex (PFC) (area 46 of Brodmann), (3) the frontal eye field (FEF), or (4) the supplementary motor area (SMA). As these 4 types of lesions were located either in the right or the left cerebral hemisphere, patients were divided into 8 groups. Saccade latency, in the saccade task, and the percentage of errors (misdirected saccades made towards the visual target), in the antisaccade task, were compared in each group of patients with the values of 20 control subjects. In the saccade task, saccade latency was significantly increased bilaterally in the right PPC group. In the left PPC group, the increase in latency was less marked, and significant only for saccades made contralaterally to the lesion. In the different frontal groups, latency was unchanged or only slightly increased. These results confirm that the main area facilitating the triggering of reflexive visually-guided saccades is located in the PPC, in or near the superior part of the angular gyrus. The difference between right and left parietal lesions could be due to the predominance of the right hemisphere in the control of these saccades. In the antisaccade task, the percentage of errors was significantly increased bilaterally in both PFC groups compared with the control group and also to the FEF and SMA group. These results suggest that the PFC is the main area in the cerebral hemisphere inhibiting reflexive visually-guided saccades.